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The Estrogen-Related Receptor α Inverse Agonist XCT 790 Is a Nanomolar Mitochondrial Uncoupler

[Image: see text] XCT 790 is widely used to inhibit estrogen-related receptor α (ERRα) activity as an inverse agonist. Here, we report that XCT 790 potently activates AMP kinase (AMPK) in a dose-dependent and ERRα-independent manner, with active concentrations more than 25-fold below those typically...

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Detalles Bibliográficos
Autores principales:	Eskiocak, Banu, Ali, Aktar, White, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116149/ https://www.ncbi.nlm.nih.gov/pubmed/24999922 http://dx.doi.org/10.1021/bi500737n

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