Cargando…
Extracellular HCV-Core Protein Induces an Immature Regulatory Phenotype in NK Cells: Implications for Outcome of Acute Infection
BACKGROUND: Hepatitis C viral (HCV) proteins, including core, demonstrate immuno-modulatory properties; however, the effect of extracellular core on natural killer (NK) cells has not previously been investigated. AIMS: To characterise NKs in acute HCV infection over time, and, to examine the effect...
Autores principales: | Golden-Mason, Lucy, Hahn, Young S., Strong, Michael, Cheng, Linling, Rosen, Hugo R. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116173/ https://www.ncbi.nlm.nih.gov/pubmed/25076408 http://dx.doi.org/10.1371/journal.pone.0103219 |
Ejemplares similares
-
Single-cell transcriptomic analyses of T cells in chronic HCV-infected patients dominated by DAA-induced interferon signaling changes
por: Burchill, Matthew A., et al.
Publicado: (2021) -
Transduction of Human T Cells with a Novel T-Cell Receptor Confers Anti-HCV Reactivity
por: Zhang, Yi, et al.
Publicado: (2010) -
Chronic HCV Infection Affects the NK Cell Phenotype in the Blood More than in the Liver
por: Cosgrove, Cormac, et al.
Publicado: (2014) -
Hepatitis C Virus Core Protein Inhibits Interferon Production by a Human Plasmacytoid Dendritic Cell Line and Dysregulates Interferon Regulatory Factor-7 and Signal Transducer and Activator of Transcription (STAT) 1 Protein Expression
por: Stone, Amy E. L., et al.
Publicado: (2014) -
Increased CD56(bright) NK cells in HIV-HCV co-infection and HCV mono-infection are associated with distinctive alterations of their phenotype
por: Bhardwaj, Suvercha, et al.
Publicado: (2016)