Interferon Regulatory Factor-5 Deficiency Ameliorates Disease Severity in the MRL/lpr Mouse Model of Lupus in the Absence of a Mutation in DOCK2

Interferon regulatory factor 5 (IRF5) polymorphisms are strongly associated with an increased risk of developing the autoimmune disease systemic lupus erythematosus. In mouse lupus models, IRF5-deficiency was shown to reduce disease severity consistent with an important role for IRF5 in disease path...

Descripción completa

Detalles Bibliográficos
Autores principales: Yasuda, Kei, Watkins, Amanda A., Kochar, Guneet S., Wilson, Gabriella E., Laskow, Bari, Richez, Christophe, Bonegio, Ramon G., Rifkin, Ian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116215/
https://www.ncbi.nlm.nih.gov/pubmed/25076492
http://dx.doi.org/10.1371/journal.pone.0103478

Ejemplares similares

Ejemplares similares