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Aspiration-Related Deaths in 57 Consecutive Patients: Autopsy Study

BACKGROUND: Aspiration can cause a diverse spectrum of pulmonary disorders some of which can lead to death but can be difficult to diagnose. PATIENTS AND METHODS: The medical records and autopsy findings of 57 consecutive patients in whom aspiration was the immediate cause of death at Mayo Clinic (R...

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Autores principales: Hu, Xiaowen, Yi, Eunhee S., Ryu, Jay H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116222/
https://www.ncbi.nlm.nih.gov/pubmed/25076409
http://dx.doi.org/10.1371/journal.pone.0103795
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author Hu, Xiaowen
Yi, Eunhee S.
Ryu, Jay H.
author_facet Hu, Xiaowen
Yi, Eunhee S.
Ryu, Jay H.
author_sort Hu, Xiaowen
collection PubMed
description BACKGROUND: Aspiration can cause a diverse spectrum of pulmonary disorders some of which can lead to death but can be difficult to diagnose. PATIENTS AND METHODS: The medical records and autopsy findings of 57 consecutive patients in whom aspiration was the immediate cause of death at Mayo Clinic (Rochester, MN, USA) over a 9-yr period, from January 1 2004 to December 31 2012 were analyzed. RESULTS: The median age at death was 72 years (range, 13–95 years) and included 39 (68%) males. The most common symptom before death was dyspnea (63%) and chest radiography revealed bilateral infiltrates in the majority (81%). Most common precipitating factors for aspiration were depressed consciousness (46%) and dysphagia (44%). Aspiration-related syndromes leading to death were aspiration pneumonia in 26 (46%), aspiration pneumonitis in 25 (44%), and large airway obstruction in 6 patients (11%). Aspiration was clinically unsuspected in 19 (33%) patients. Antimicrobial therapy had been empirically administered to most patients (90%) with aspiration pneumonia and aspiration pneumonitis. CONCLUSION: We conclude aspiration-related deaths occur most commonly in the elderly with identifiable risks and presenting bilateral pulmonary infiltrates. One-third of these aspiration-related pulmonary syndromes were clinically unsuspected at the time of death.
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spelling pubmed-41162222014-08-04 Aspiration-Related Deaths in 57 Consecutive Patients: Autopsy Study Hu, Xiaowen Yi, Eunhee S. Ryu, Jay H. PLoS One Research Article BACKGROUND: Aspiration can cause a diverse spectrum of pulmonary disorders some of which can lead to death but can be difficult to diagnose. PATIENTS AND METHODS: The medical records and autopsy findings of 57 consecutive patients in whom aspiration was the immediate cause of death at Mayo Clinic (Rochester, MN, USA) over a 9-yr period, from January 1 2004 to December 31 2012 were analyzed. RESULTS: The median age at death was 72 years (range, 13–95 years) and included 39 (68%) males. The most common symptom before death was dyspnea (63%) and chest radiography revealed bilateral infiltrates in the majority (81%). Most common precipitating factors for aspiration were depressed consciousness (46%) and dysphagia (44%). Aspiration-related syndromes leading to death were aspiration pneumonia in 26 (46%), aspiration pneumonitis in 25 (44%), and large airway obstruction in 6 patients (11%). Aspiration was clinically unsuspected in 19 (33%) patients. Antimicrobial therapy had been empirically administered to most patients (90%) with aspiration pneumonia and aspiration pneumonitis. CONCLUSION: We conclude aspiration-related deaths occur most commonly in the elderly with identifiable risks and presenting bilateral pulmonary infiltrates. One-third of these aspiration-related pulmonary syndromes were clinically unsuspected at the time of death. Public Library of Science 2014-07-30 /pmc/articles/PMC4116222/ /pubmed/25076409 http://dx.doi.org/10.1371/journal.pone.0103795 Text en © 2014 Hu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hu, Xiaowen
Yi, Eunhee S.
Ryu, Jay H.
Aspiration-Related Deaths in 57 Consecutive Patients: Autopsy Study
title Aspiration-Related Deaths in 57 Consecutive Patients: Autopsy Study
title_full Aspiration-Related Deaths in 57 Consecutive Patients: Autopsy Study
title_fullStr Aspiration-Related Deaths in 57 Consecutive Patients: Autopsy Study
title_full_unstemmed Aspiration-Related Deaths in 57 Consecutive Patients: Autopsy Study
title_short Aspiration-Related Deaths in 57 Consecutive Patients: Autopsy Study
title_sort aspiration-related deaths in 57 consecutive patients: autopsy study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116222/
https://www.ncbi.nlm.nih.gov/pubmed/25076409
http://dx.doi.org/10.1371/journal.pone.0103795
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