JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin

Cofilin, an actin-binding protein which disassembles actin filaments, plays an important role in invasion and metastasis. Here, we discover that JG6, an oligomannurarate sulfate, binds to cofilin, suppresses the migration of human breast cancer cells and cancer metastasis in breast cancer xenograft...

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Detalles Bibliográficos
Autores principales: Huang, Xun, Sun, Danni, Pan, Qiuming, Wen, Weiwei, Chen, Yi, Xin, Xianliang, Huang, Min, Ding, Jian, Geng, Meiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116503/
https://www.ncbi.nlm.nih.gov/pubmed/25003327
Descripción
Sumario:Cofilin, an actin-binding protein which disassembles actin filaments, plays an important role in invasion and metastasis. Here, we discover that JG6, an oligomannurarate sulfate, binds to cofilin, suppresses the migration of human breast cancer cells and cancer metastasis in breast cancer xenograft model. Mechanistically, JG6 occupies actin-binding sites of cofilin, thereby disrupting cofilin modulated actin turnover. Our results highlight the significance of cofilin in cancer and suggest JG6, a cofilin inhibitor, to treat metastatic cancer.

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