JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin

Cofilin, an actin-binding protein which disassembles actin filaments, plays an important role in invasion and metastasis. Here, we discover that JG6, an oligomannurarate sulfate, binds to cofilin, suppresses the migration of human breast cancer cells and cancer metastasis in breast cancer xenograft...

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Detalles Bibliográficos
Autores principales: Huang, Xun, Sun, Danni, Pan, Qiuming, Wen, Weiwei, Chen, Yi, Xin, Xianliang, Huang, Min, Ding, Jian, Geng, Meiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116503/
https://www.ncbi.nlm.nih.gov/pubmed/25003327
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author Huang, Xun
Sun, Danni
Pan, Qiuming
Wen, Weiwei
Chen, Yi
Xin, Xianliang
Huang, Min
Ding, Jian
Geng, Meiyu
author_facet Huang, Xun
Sun, Danni
Pan, Qiuming
Wen, Weiwei
Chen, Yi
Xin, Xianliang
Huang, Min
Ding, Jian
Geng, Meiyu
author_sort Huang, Xun
collection PubMed
description Cofilin, an actin-binding protein which disassembles actin filaments, plays an important role in invasion and metastasis. Here, we discover that JG6, an oligomannurarate sulfate, binds to cofilin, suppresses the migration of human breast cancer cells and cancer metastasis in breast cancer xenograft model. Mechanistically, JG6 occupies actin-binding sites of cofilin, thereby disrupting cofilin modulated actin turnover. Our results highlight the significance of cofilin in cancer and suggest JG6, a cofilin inhibitor, to treat metastatic cancer.
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spelling pubmed-41165032014-08-04 JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin Huang, Xun Sun, Danni Pan, Qiuming Wen, Weiwei Chen, Yi Xin, Xianliang Huang, Min Ding, Jian Geng, Meiyu Oncotarget Research Paper Cofilin, an actin-binding protein which disassembles actin filaments, plays an important role in invasion and metastasis. Here, we discover that JG6, an oligomannurarate sulfate, binds to cofilin, suppresses the migration of human breast cancer cells and cancer metastasis in breast cancer xenograft model. Mechanistically, JG6 occupies actin-binding sites of cofilin, thereby disrupting cofilin modulated actin turnover. Our results highlight the significance of cofilin in cancer and suggest JG6, a cofilin inhibitor, to treat metastatic cancer. Impact Journals LLC 2014-05-12 /pmc/articles/PMC4116503/ /pubmed/25003327 Text en Copyright: © 2014 Huang et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Huang, Xun
Sun, Danni
Pan, Qiuming
Wen, Weiwei
Chen, Yi
Xin, Xianliang
Huang, Min
Ding, Jian
Geng, Meiyu
JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin
title JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin
title_full JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin
title_fullStr JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin
title_full_unstemmed JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin
title_short JG6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin
title_sort jg6, a novel marine-derived oligosaccharide, suppresses breast cancer metastasis via binding to cofilin
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116503/
https://www.ncbi.nlm.nih.gov/pubmed/25003327
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