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Clinical features and mortality in Chinese with lupus nephritis and neuropsychiatric lupus: A 124-patient study

BACKGROUND: Few investigation has focused on the patients with lupus nephritis (LN) and neuropsychiatric systemic lupus erythematosus (NPSLE). This study was aimed to investigate the clinical features, mortality, and the predictors for mortality of this group of patients. MATERIALS AND METHODS: Medi...

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Autores principales: Feng, Min, Lv, Jun, Fu, Sha, Liu, Bo, Tang, Ying, Wan, Xia, Liang, Peifen, Zeng, Yuchun, Li, Jingao, Lu, Yanying, Li, Xiaomei, Xu, Anping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116572/
https://www.ncbi.nlm.nih.gov/pubmed/25097623
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author Feng, Min
Lv, Jun
Fu, Sha
Liu, Bo
Tang, Ying
Wan, Xia
Liang, Peifen
Zeng, Yuchun
Li, Jingao
Lu, Yanying
Li, Xiaomei
Xu, Anping
author_facet Feng, Min
Lv, Jun
Fu, Sha
Liu, Bo
Tang, Ying
Wan, Xia
Liang, Peifen
Zeng, Yuchun
Li, Jingao
Lu, Yanying
Li, Xiaomei
Xu, Anping
author_sort Feng, Min
collection PubMed
description BACKGROUND: Few investigation has focused on the patients with lupus nephritis (LN) and neuropsychiatric systemic lupus erythematosus (NPSLE). This study was aimed to investigate the clinical features, mortality, and the predictors for mortality of this group of patients. MATERIALS AND METHODS: Medical records were retrospectively reviewed in Sun Yat-sen Memorial Hospital from 1996 to 2012. Data of demographic information, clinical manifestations, laboratory tests, SLE disease activity index 2000 (SLEDAI-2K) score, diagnosis, complications, treatment, and mortality was collected. RESULTS: A total of 124 patients were included in our study. Thirty-five (29.1%) patients had glomerular filtration rate <60 ml/min/1.73 m(2), while 24 (19.4%) experienced acute kidney injury (AKI). Thirteen of the 19 American College of Rheumatology defined NPSLE syndromes were identified. The most frequent manifestation was seizure disorder (56/124, 45.2%), followed by psychosis (37/124, 29.8%) and cerebrovascular disease (35/124, 28.2%). One hundred and five (84.7%) patients had SLEDAI-2K scores ≥15, the mean of which was 21.5 ± 6.2. The mortality during hospitalization was 12.9% (16/124) with NP involvement itself being the leading cause of death (7/16, 43.8%). Multivariate logistic regression confirmed that age <14 years at onset of NPSLE (odds ratios [OR]: 9.95, 95% confidence intervals [CI]: 1.43-69.36, P = 0.020), AKI (OR: 10.40, 95% CI: 2.33-46.48, P = 0.002) and pneumonia (OR: 4.52, 95% CI: 1.14-17.96, P = 0.032) were risk factors for mortality, while cyclophosphamide (CYC) treatment (OR: 0.09, 95% CI: 0.02-0.54, P = 0.008) was a protective factor. CONCLUSION: Most of SLE patients with LN and new-onset NPSLE are in an active disease state. NP manifestation itself was the leading cause of death during hospitalization. Childhood-onset NPSLE, AKI and pneumonia might be predictors of mortality, whereas CYC treatment might improve the prognosis.
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spelling pubmed-41165722014-08-05 Clinical features and mortality in Chinese with lupus nephritis and neuropsychiatric lupus: A 124-patient study Feng, Min Lv, Jun Fu, Sha Liu, Bo Tang, Ying Wan, Xia Liang, Peifen Zeng, Yuchun Li, Jingao Lu, Yanying Li, Xiaomei Xu, Anping J Res Med Sci Original Article BACKGROUND: Few investigation has focused on the patients with lupus nephritis (LN) and neuropsychiatric systemic lupus erythematosus (NPSLE). This study was aimed to investigate the clinical features, mortality, and the predictors for mortality of this group of patients. MATERIALS AND METHODS: Medical records were retrospectively reviewed in Sun Yat-sen Memorial Hospital from 1996 to 2012. Data of demographic information, clinical manifestations, laboratory tests, SLE disease activity index 2000 (SLEDAI-2K) score, diagnosis, complications, treatment, and mortality was collected. RESULTS: A total of 124 patients were included in our study. Thirty-five (29.1%) patients had glomerular filtration rate <60 ml/min/1.73 m(2), while 24 (19.4%) experienced acute kidney injury (AKI). Thirteen of the 19 American College of Rheumatology defined NPSLE syndromes were identified. The most frequent manifestation was seizure disorder (56/124, 45.2%), followed by psychosis (37/124, 29.8%) and cerebrovascular disease (35/124, 28.2%). One hundred and five (84.7%) patients had SLEDAI-2K scores ≥15, the mean of which was 21.5 ± 6.2. The mortality during hospitalization was 12.9% (16/124) with NP involvement itself being the leading cause of death (7/16, 43.8%). Multivariate logistic regression confirmed that age <14 years at onset of NPSLE (odds ratios [OR]: 9.95, 95% confidence intervals [CI]: 1.43-69.36, P = 0.020), AKI (OR: 10.40, 95% CI: 2.33-46.48, P = 0.002) and pneumonia (OR: 4.52, 95% CI: 1.14-17.96, P = 0.032) were risk factors for mortality, while cyclophosphamide (CYC) treatment (OR: 0.09, 95% CI: 0.02-0.54, P = 0.008) was a protective factor. CONCLUSION: Most of SLE patients with LN and new-onset NPSLE are in an active disease state. NP manifestation itself was the leading cause of death during hospitalization. Childhood-onset NPSLE, AKI and pneumonia might be predictors of mortality, whereas CYC treatment might improve the prognosis. Medknow Publications & Media Pvt Ltd 2014-05 /pmc/articles/PMC4116572/ /pubmed/25097623 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Feng, Min
Lv, Jun
Fu, Sha
Liu, Bo
Tang, Ying
Wan, Xia
Liang, Peifen
Zeng, Yuchun
Li, Jingao
Lu, Yanying
Li, Xiaomei
Xu, Anping
Clinical features and mortality in Chinese with lupus nephritis and neuropsychiatric lupus: A 124-patient study
title Clinical features and mortality in Chinese with lupus nephritis and neuropsychiatric lupus: A 124-patient study
title_full Clinical features and mortality in Chinese with lupus nephritis and neuropsychiatric lupus: A 124-patient study
title_fullStr Clinical features and mortality in Chinese with lupus nephritis and neuropsychiatric lupus: A 124-patient study
title_full_unstemmed Clinical features and mortality in Chinese with lupus nephritis and neuropsychiatric lupus: A 124-patient study
title_short Clinical features and mortality in Chinese with lupus nephritis and neuropsychiatric lupus: A 124-patient study
title_sort clinical features and mortality in chinese with lupus nephritis and neuropsychiatric lupus: a 124-patient study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116572/
https://www.ncbi.nlm.nih.gov/pubmed/25097623
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