Cargando…

Evaluation of O6-methylguanine-DNA methyltransferase enzyme expression effect on survival of patients with Grade 4 brain astrocytoma

BACKGROUND: High-grade astrocytoma (Grade 4) or glioblastoma multiforme (GBM) are deadly brain tumors. New therapies attempt to increase lifetime and quality of life in patients with malignant astrocytoma. O6-methylguanine-DNA methyltransferase (MGMT) enzyme expression may be effective in prognosis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hemati, Simin, Sayadi, Ali, Mahzooni, Parvin, Sirous, Mehry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2014
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116574/ https://www.ncbi.nlm.nih.gov/pubmed/25097625

Ejemplares similares

Effect of alternative temozolomide schedules on glioblastoma O(6)-methylguanine-DNA methyltransferase activity and survival
por: Robinson, C G, et al.
Publicado: (2010)

The role of direct DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) in high grade malignant glioma
por: Manoj, M Jeru, et al.
Publicado: (2014)

High-dose radiotherapy in newly diagnosed low-grade gliomas with nonmethylated O(6)-methylguanine-DNA methyltransferase
por: Liu, Yanwei, et al.
Publicado: (2021)

O6-methylguanine-DNA methyltransferase activities in biopsies of human melanoma tumours.
por: Egyházi, S., et al.
Publicado: (1995)

Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells.
por: Kokkinakis, D. M., et al.
Publicado: (1997)

O(6)-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis
por: Altamura, Gennaro, et al.
Publicado: (2012)

Regulation of expression of O(6)-methylguanine-DNA methyltransferase and the treatment of glioblastoma (Review)
por: CABRINI, GIULIO, et al.
Publicado: (2015)

O(6)‐Methylguanine‐DNA Methyltransferase (MGMT) as a Determinant of Resistance to Camptothecin Derivatives
por: Okamoto, Ryo, et al.
Publicado: (2002)

O(6)-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy
por: Yu, Wei, et al.
Publicado: (2020)

Diffusion Kurtosis Imaging Reflects Glial Fibrillary Acidic Protein (GFAP), Topo IIα, and O(6)-Methylguanine-DNA Methyltransferase (MGMT) Expression in Astrocytomas
por: Wang, Xiao-chun, et al.
Publicado: (2018)

Inhibition of O(6)-methylguanine-DNA methyltransferase by an alkyltransferase-like protein from Escherichia coli
por: Pearson, Steven J., et al.
Publicado: (2005)

Atomic Insight into the Altered O(6)-Methylguanine-DNA Methyltransferase Protein Architecture in Gastric Cancer
por: Chikan, Naveed Anjum, et al.
Publicado: (2015)

O(6)-methylguanine DNA methyltransferase as a promising target for the treatment of temozolomide-resistant gliomas
por: Fan, C-H, et al.
Publicado: (2013)

Prognostic value of O(6)-methylguanine-DNA methyltransferase methylation in isocitrate dehydrogenase mutant gliomas
por: Lam, Keng, et al.
Publicado: (2022)

Inactivation of O(6)‐Methylguanine‐DNA Methyltransferase in Human Lung Adenocarcinoma Relates to High‐grade Histology and Worse Prognosis among Smokers
por: Hayashi, Hiroyuki, et al.
Publicado: (2002)

O(6)-methylguanine-DNA methyltransferase depletion and DNA damage in patients with melanoma treated with temozolomide alone or with lomeguatrib
por: Watson, A J, et al.
Publicado: (2009)

Induced Synthesis of O(6)‐Methylguanine‐DNA Methyltransferase in Rat Hepatoma Cells Exposed to DNA‐damaging Agents
por: Fukuhara, Masao, et al.
Publicado: (1992)

Inactivation of O(6)-methylguanine-DNA methyltransferase by promoter CpG island hypermethylation in gastric cancers
por: Bae, S I, et al.
Publicado: (2002)

O(6)-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma
por: Ma, S, et al.
Publicado: (2003)

O(6)-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies
por: Sasai, Ken, et al.
Publicado: (2007)

O6-methylguanine-DNA methyltransferase in pretreatment tumour biopsies as a predictor of response to temozolomide in melanoma.
por: Middleton, M. R., et al.
Publicado: (1998)

O-6-methylguanine DNA methyltransferase is a favorable biomarker with proliferation suppressive potential in Breast Cancer
por: Lin, Danxia, et al.
Publicado: (2020)

Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics
por: Lasri, Ayoub, et al.
Publicado: (2020)

O(6)-methylguanine DNA methyltransferase and glucose transporter 2 in foregut and hindgut gastrointestinal neuroendocrine neoplasms
por: Watanabe, Hirofumi, et al.
Publicado: (2020)

Autophagy deficiency downregulates O(6)methylguanine-DNA methyltransferase and increases chemosensitivity of liver cancer cells
por: Hou, Xiaojuan, et al.
Publicado: (2021)

Roles of the hydroxy group of tyrosine in crystal structures of Sulfurisphaera tokodaii O (6)-methylguanine-DNA methyltransferase
por: Kikuchi, Makiko, et al.
Publicado: (2021)

Erratum to: Prognostic value of O(6)-methylguanine-DNA methyltransferase methylation in isocitrate dehydrogenase mutant gliomas
Publicado: (2022)

Novel synthesis of O(6)-alkylguanine containing oligodeoxyribonucleotides as substrates for the human DNA repair protein, O(6)-methylguanine DNA methyltransferase (MGMT)
por: Shibata, Takayuki, et al.
Publicado: (2006)

The nitrosated bile acid DNA lesion O(6)-carboxymethylguanine is a substrate for the human DNA repair protein O(6)-methylguanine-DNA methyltransferase
por: Senthong, Pattama, et al.
Publicado: (2013)

Activity of irinotecan and temozolomide in the presence of O(6)-methylguanine-DNA methyltransferase inhibition in neuroblastoma pre-clinical models
por: Cai, W, et al.
Publicado: (2010)

O6-methylguanine-DNA methyltransferase (MGMT) Promoter methylation is a rare event in soft tissue sarcoma
por: Jakob, Jens, et al.
Publicado: (2012)

O(6)-Methylguanine-DNA methyltransferase status in neuroendocrine tumours: prognostic relevance and association with response to alkylating agents
por: Walter, T, et al.
Publicado: (2015)

The Impact of O6-Methylguanine-DNA Methyltransferase (MGMT) Promoter Methylation on the Outcomes of Patients with Leiomyosarcoma Treated with Dacarbazine
por: Cannella, Lucia, et al.
Publicado: (2023)

KDM6B promotes PARthanatos via suppression of O(6)-methylguanine DNA methyltransferase repair and sustained checkpoint response
por: Yang, Mingming, et al.
Publicado: (2022)

Combination therapy with capecitabine and temozolomide in patients with low and high grade neuroendocrine tumors, with an exploratory analysis of O(6)-methylguanine DNA methyltransferase as a biomarker for response
por: Owen, Dwight H., et al.
Publicado: (2017)

Both base excision repair and O(6)-methylguanine-DNA methyltransferase protect against methylation-induced colon carcinogenesis
por: Wirtz, Stefan, et al.
Publicado: (2010)

Immunohistochemical Assessment of O(6)-Methylguanine-DNA Methyltransferase (MGMT) and Its Relationship with p53 Expression in Endometrial Cancers
por: Lee, Kyung Eun
Publicado: (2013)

In Silico Prediction of O(6)-Methylguanine-DNA Methyltransferase Inhibitory Potency of Base Analogs with QSAR and Machine Learning Methods
por: Sun, Guohui, et al.
Publicado: (2018)

O6-methylguanine-DNA Methyltransferase Promoter Methylation in Patients with Rectal Adenocarcinoma After Chemoradiotherapy Treatment: Clinical Implications
por: Oliver, Jaime A., et al.
Publicado: (2019)

A female adnexal tumor of probable Wolffian origin showing positive O-6-methylguanine-DNA methyltransferase methylation
por: Kwon, Min Jung, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kecs3f6is3og32vf9e4tpomsbq