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The role of animal models in tendon research
Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain and lead to complete rupture of the tendon, which often requires surgical repair. Due in part to the large spectrum of tendon pathologies, these disorders continue to be a clinical challenge. Animal models are...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
British Editorial Society of Bone and Joint Surgery
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116644/ https://www.ncbi.nlm.nih.gov/pubmed/24958818 http://dx.doi.org/10.1302/2046-3758.36.2000281 |
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author | Hast, M. W. Zuskov, A. Soslowsky, L. J. |
author_facet | Hast, M. W. Zuskov, A. Soslowsky, L. J. |
author_sort | Hast, M. W. |
collection | PubMed |
description | Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain and lead to complete rupture of the tendon, which often requires surgical repair. Due in part to the large spectrum of tendon pathologies, these disorders continue to be a clinical challenge. Animal models are often used in this field of research as they offer an attractive framework to examine the cascade of processes that occur throughout both tendon pathology and repair. This review discusses the structural, mechanical, and biological changes that occur throughout tendon pathology in animal models, as well as strategies for the improvement of tendon healing. Cite this article: Bone Joint Res 2014;3:193–202. |
format | Online Article Text |
id | pubmed-4116644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | British Editorial Society of Bone and Joint Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-41166442014-08-05 The role of animal models in tendon research Hast, M. W. Zuskov, A. Soslowsky, L. J. Bone Joint Res Specialty update: General orthopaedics Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain and lead to complete rupture of the tendon, which often requires surgical repair. Due in part to the large spectrum of tendon pathologies, these disorders continue to be a clinical challenge. Animal models are often used in this field of research as they offer an attractive framework to examine the cascade of processes that occur throughout both tendon pathology and repair. This review discusses the structural, mechanical, and biological changes that occur throughout tendon pathology in animal models, as well as strategies for the improvement of tendon healing. Cite this article: Bone Joint Res 2014;3:193–202. British Editorial Society of Bone and Joint Surgery 2014-06-01 /pmc/articles/PMC4116644/ /pubmed/24958818 http://dx.doi.org/10.1302/2046-3758.36.2000281 Text en ©2014 The British Editorial Society of Bone & Joint Surgery ©2014 The British Editorial Society of Bone & Joint Surgery. This is an open-access article distributed under the terms of the Creative Commons Attributions licence, which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited. |
spellingShingle | Specialty update: General orthopaedics Hast, M. W. Zuskov, A. Soslowsky, L. J. The role of animal models in tendon research |
title | The role of animal models in tendon research |
title_full | The role of animal models in tendon research |
title_fullStr | The role of animal models in tendon research |
title_full_unstemmed | The role of animal models in tendon research |
title_short | The role of animal models in tendon research |
title_sort | role of animal models in tendon research |
topic | Specialty update: General orthopaedics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116644/ https://www.ncbi.nlm.nih.gov/pubmed/24958818 http://dx.doi.org/10.1302/2046-3758.36.2000281 |
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