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The role of animal models in tendon research

Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain and lead to complete rupture of the tendon, which often requires surgical repair. Due in part to the large spectrum of tendon pathologies, these disorders continue to be a clinical challenge. Animal models are...

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Detalles Bibliográficos
Autores principales: Hast, M. W., Zuskov, A., Soslowsky, L. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: British Editorial Society of Bone and Joint Surgery 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116644/
https://www.ncbi.nlm.nih.gov/pubmed/24958818
http://dx.doi.org/10.1302/2046-3758.36.2000281
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author Hast, M. W.
Zuskov, A.
Soslowsky, L. J.
author_facet Hast, M. W.
Zuskov, A.
Soslowsky, L. J.
author_sort Hast, M. W.
collection PubMed
description Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain and lead to complete rupture of the tendon, which often requires surgical repair. Due in part to the large spectrum of tendon pathologies, these disorders continue to be a clinical challenge. Animal models are often used in this field of research as they offer an attractive framework to examine the cascade of processes that occur throughout both tendon pathology and repair. This review discusses the structural, mechanical, and biological changes that occur throughout tendon pathology in animal models, as well as strategies for the improvement of tendon healing. Cite this article: Bone Joint Res 2014;3:193–202.
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spelling pubmed-41166442014-08-05 The role of animal models in tendon research Hast, M. W. Zuskov, A. Soslowsky, L. J. Bone Joint Res Specialty update: General orthopaedics Tendinopathy is a debilitating musculoskeletal condition which can cause significant pain and lead to complete rupture of the tendon, which often requires surgical repair. Due in part to the large spectrum of tendon pathologies, these disorders continue to be a clinical challenge. Animal models are often used in this field of research as they offer an attractive framework to examine the cascade of processes that occur throughout both tendon pathology and repair. This review discusses the structural, mechanical, and biological changes that occur throughout tendon pathology in animal models, as well as strategies for the improvement of tendon healing. Cite this article: Bone Joint Res 2014;3:193–202. British Editorial Society of Bone and Joint Surgery 2014-06-01 /pmc/articles/PMC4116644/ /pubmed/24958818 http://dx.doi.org/10.1302/2046-3758.36.2000281 Text en ©2014 The British Editorial Society of Bone & Joint Surgery ©2014 The British Editorial Society of Bone & Joint Surgery. This is an open-access article distributed under the terms of the Creative Commons Attributions licence, which permits unrestricted use, distribution, and reproduction in any medium, but not for commercial gain, provided the original author and source are credited.
spellingShingle Specialty update: General orthopaedics
Hast, M. W.
Zuskov, A.
Soslowsky, L. J.
The role of animal models in tendon research
title The role of animal models in tendon research
title_full The role of animal models in tendon research
title_fullStr The role of animal models in tendon research
title_full_unstemmed The role of animal models in tendon research
title_short The role of animal models in tendon research
title_sort role of animal models in tendon research
topic Specialty update: General orthopaedics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116644/
https://www.ncbi.nlm.nih.gov/pubmed/24958818
http://dx.doi.org/10.1302/2046-3758.36.2000281
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