ASC has extracellular and prionoid activities that propagate inflammation

Microbes or danger signals trigger inflammasome sensors, which induce polymerization of the adapter ASC and assembly of an ASC speck. ASC specks recruit and activate caspase-1, which induces IL-1β cytokine maturation and pyroptotic cell death. Here we show that after pyroptosis ASC specks accumulate...

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Detalles Bibliográficos
Autores principales: Franklin, Bernardo S., Bossaller, Lukas, De Nardo, Dominic, Ratter, Jacqueline M., Stutz, Andrea, Engels, Gudrun, Brenker, Christoph, Nordhoff, Mark, Mirandola, Sandra R., Al-Amoudi, Ashraf, Mangan, Matthew, Zimmer, Sebastian, Monks, Brian, Fricke, Martin, Schmidt, Reinhold E., Espevik, Terje, Jones, Bernadette, Jarnicki, Andrew G., Hansbro, Philip M., Busto, Patricia, Marshak-Rothstein, Ann, Hornemann, Simone, Aguzzi, Adriano, Kastenmüller, Wolfgang, Latz, Eicke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116676/
https://www.ncbi.nlm.nih.gov/pubmed/24952505
http://dx.doi.org/10.1038/ni.2913

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