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New cellular and molecular approaches to ageing brain
The last decade has witnessed a mammoth progress in the area of brain ageing. Recent gene profiling and brain imaging techniques have made it possible to explore the dark areas of ageing neurons in a new molecular perspective. Many conserved pathways and cellular and molecular mechanisms particularl...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Indian Academy of Neurosciences
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117059/ https://www.ncbi.nlm.nih.gov/pubmed/25205996 http://dx.doi.org/10.5214/ans.0972.7531.190410 |
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author | Tripathi, Anurag |
author_facet | Tripathi, Anurag |
author_sort | Tripathi, Anurag |
collection | PubMed |
description | The last decade has witnessed a mammoth progress in the area of brain ageing. Recent gene profiling and brain imaging techniques have made it possible to explore the dark areas of ageing neurons in a new molecular perspective. Many conserved pathways and cellular and molecular mechanisms particularly nuclear mitochondrial molecular interactions are known now. Disruptions in mitochondrial function and reduction in cellular antioxidative and immunoproteins contribute to generation of reactive oxygen species (ROS) which leads to deteriorated adult neurogenesis, reduced white matter and compromised neural plasticity. The overall deteriorated structure and function of neurons is manifested in form of cognitive decline and prolonged neurodegenerative disorders. Dietary restrictions (DR), physical and mental activities however have been shown to counter these ailments. However more precise molecular dynamics at protein levels is still debatable which is the future task for neuroscientists. |
format | Online Article Text |
id | pubmed-4117059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Indian Academy of Neurosciences |
record_format | MEDLINE/PubMed |
spelling | pubmed-41170592014-09-09 New cellular and molecular approaches to ageing brain Tripathi, Anurag Ann Neurosci Comprehensive Review The last decade has witnessed a mammoth progress in the area of brain ageing. Recent gene profiling and brain imaging techniques have made it possible to explore the dark areas of ageing neurons in a new molecular perspective. Many conserved pathways and cellular and molecular mechanisms particularly nuclear mitochondrial molecular interactions are known now. Disruptions in mitochondrial function and reduction in cellular antioxidative and immunoproteins contribute to generation of reactive oxygen species (ROS) which leads to deteriorated adult neurogenesis, reduced white matter and compromised neural plasticity. The overall deteriorated structure and function of neurons is manifested in form of cognitive decline and prolonged neurodegenerative disorders. Dietary restrictions (DR), physical and mental activities however have been shown to counter these ailments. However more precise molecular dynamics at protein levels is still debatable which is the future task for neuroscientists. Indian Academy of Neurosciences 2012-10 /pmc/articles/PMC4117059/ /pubmed/25205996 http://dx.doi.org/10.5214/ans.0972.7531.190410 Text en Copyright © 2012, Annals of Neurosciences |
spellingShingle | Comprehensive Review Tripathi, Anurag New cellular and molecular approaches to ageing brain |
title | New cellular and molecular approaches to ageing brain |
title_full | New cellular and molecular approaches to ageing brain |
title_fullStr | New cellular and molecular approaches to ageing brain |
title_full_unstemmed | New cellular and molecular approaches to ageing brain |
title_short | New cellular and molecular approaches to ageing brain |
title_sort | new cellular and molecular approaches to ageing brain |
topic | Comprehensive Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117059/ https://www.ncbi.nlm.nih.gov/pubmed/25205996 http://dx.doi.org/10.5214/ans.0972.7531.190410 |
work_keys_str_mv | AT tripathianurag newcellularandmolecularapproachestoageingbrain |