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Morphometric Differences in Planum Temporale in Schizophrenia and Bipolar Disorder Revealed by Statistical Analysis of Labeled Cortical Depth Maps

Differences in cortical thickness in the lateral temporal lobe, including the planum temporale (PT), have been reported in MRI studies of schizophrenia (SCZ) and bipolar disorder (BPD) patients. Most of these studies have used a single-valued global or local measure for thickness. However, additiona...

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Autores principales: Ratnanather, J. Tilak, Cebron, Shannon, Ceyhan, Elvan, Postell, Elizabeth, Pisano, Dominic V., Poynton, Clare B., Crocker, Britni, Honeycutt, Nancy A., Mahon, Pamela B., Barta, Patrick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117114/
https://www.ncbi.nlm.nih.gov/pubmed/25132825
http://dx.doi.org/10.3389/fpsyt.2014.00094
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author Ratnanather, J. Tilak
Cebron, Shannon
Ceyhan, Elvan
Postell, Elizabeth
Pisano, Dominic V.
Poynton, Clare B.
Crocker, Britni
Honeycutt, Nancy A.
Mahon, Pamela B.
Barta, Patrick E.
author_facet Ratnanather, J. Tilak
Cebron, Shannon
Ceyhan, Elvan
Postell, Elizabeth
Pisano, Dominic V.
Poynton, Clare B.
Crocker, Britni
Honeycutt, Nancy A.
Mahon, Pamela B.
Barta, Patrick E.
author_sort Ratnanather, J. Tilak
collection PubMed
description Differences in cortical thickness in the lateral temporal lobe, including the planum temporale (PT), have been reported in MRI studies of schizophrenia (SCZ) and bipolar disorder (BPD) patients. Most of these studies have used a single-valued global or local measure for thickness. However, additional and complementary information can be obtained by generating labeled cortical distance maps (LCDMs), which are distances of labeled gray matter (GM) voxels from the nearest point on the GM/white matter (WM) (inner) cortical surface. Statistical analyses of pooled and censored LCDM distances reveal subtle differences in PT between SCZ and BPD groups from data generated by Ratnanather et al. (Schizophrenia Research, http://dx.doi.org/10.1016/j.schres.2013.08.014). These results confirm that the left planum temporale (LPT) is more sensitive than the right PT in distinguishing between SCZ, BPD, and healthy controls. Also confirmed is a strong gender effect, with a thicker PT seen in males than in females. The differences between groups at smaller distances in the LPT revealed by pooled and censored LCDM analysis suggest that SCZ and BPD have different effects on the cortical mantle close to the GM/WM surface. This is consistent with reported subtle changes in the cortical mantle observed in post-mortem studies.
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spelling pubmed-41171142014-08-15 Morphometric Differences in Planum Temporale in Schizophrenia and Bipolar Disorder Revealed by Statistical Analysis of Labeled Cortical Depth Maps Ratnanather, J. Tilak Cebron, Shannon Ceyhan, Elvan Postell, Elizabeth Pisano, Dominic V. Poynton, Clare B. Crocker, Britni Honeycutt, Nancy A. Mahon, Pamela B. Barta, Patrick E. Front Psychiatry Psychiatry Differences in cortical thickness in the lateral temporal lobe, including the planum temporale (PT), have been reported in MRI studies of schizophrenia (SCZ) and bipolar disorder (BPD) patients. Most of these studies have used a single-valued global or local measure for thickness. However, additional and complementary information can be obtained by generating labeled cortical distance maps (LCDMs), which are distances of labeled gray matter (GM) voxels from the nearest point on the GM/white matter (WM) (inner) cortical surface. Statistical analyses of pooled and censored LCDM distances reveal subtle differences in PT between SCZ and BPD groups from data generated by Ratnanather et al. (Schizophrenia Research, http://dx.doi.org/10.1016/j.schres.2013.08.014). These results confirm that the left planum temporale (LPT) is more sensitive than the right PT in distinguishing between SCZ, BPD, and healthy controls. Also confirmed is a strong gender effect, with a thicker PT seen in males than in females. The differences between groups at smaller distances in the LPT revealed by pooled and censored LCDM analysis suggest that SCZ and BPD have different effects on the cortical mantle close to the GM/WM surface. This is consistent with reported subtle changes in the cortical mantle observed in post-mortem studies. Frontiers Media S.A. 2014-08-01 /pmc/articles/PMC4117114/ /pubmed/25132825 http://dx.doi.org/10.3389/fpsyt.2014.00094 Text en Copyright © 2014 Ratnanather, Cebron, Ceyhan, Postell, Pisano, Poynton, Crocker, Honeycutt, Mahon and Barta. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Ratnanather, J. Tilak
Cebron, Shannon
Ceyhan, Elvan
Postell, Elizabeth
Pisano, Dominic V.
Poynton, Clare B.
Crocker, Britni
Honeycutt, Nancy A.
Mahon, Pamela B.
Barta, Patrick E.
Morphometric Differences in Planum Temporale in Schizophrenia and Bipolar Disorder Revealed by Statistical Analysis of Labeled Cortical Depth Maps
title Morphometric Differences in Planum Temporale in Schizophrenia and Bipolar Disorder Revealed by Statistical Analysis of Labeled Cortical Depth Maps
title_full Morphometric Differences in Planum Temporale in Schizophrenia and Bipolar Disorder Revealed by Statistical Analysis of Labeled Cortical Depth Maps
title_fullStr Morphometric Differences in Planum Temporale in Schizophrenia and Bipolar Disorder Revealed by Statistical Analysis of Labeled Cortical Depth Maps
title_full_unstemmed Morphometric Differences in Planum Temporale in Schizophrenia and Bipolar Disorder Revealed by Statistical Analysis of Labeled Cortical Depth Maps
title_short Morphometric Differences in Planum Temporale in Schizophrenia and Bipolar Disorder Revealed by Statistical Analysis of Labeled Cortical Depth Maps
title_sort morphometric differences in planum temporale in schizophrenia and bipolar disorder revealed by statistical analysis of labeled cortical depth maps
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117114/
https://www.ncbi.nlm.nih.gov/pubmed/25132825
http://dx.doi.org/10.3389/fpsyt.2014.00094
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