Accumulation of a Threonine Biosynthetic Intermediate Attenuates General Amino Acid Control by Accelerating Degradation of Gcn4 via Pho85 and Cdk8

Gcn4 is a master transcriptional regulator of amino acid and vitamin biosynthetic enzymes subject to the general amino acid control (GAAC), whose expression is upregulated in response to amino acid starvation in Saccharomyces cerevisiae. We found that accumulation of the threonine pathway intermedia...

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Detalles Bibliográficos
Autores principales: Rawal, Yashpal, Qiu, Hongfang, Hinnebusch, Alan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117449/
https://www.ncbi.nlm.nih.gov/pubmed/25079372
http://dx.doi.org/10.1371/journal.pgen.1004534

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117449/
https://www.ncbi.nlm.nih.gov/pubmed/25079372
http://dx.doi.org/10.1371/journal.pgen.1004534

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