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Phagocytic Uptake of Oxidized Heme Polymer Is Highly Cytotoxic to Macrophages

Apoptosis in macrophages is responsible for immune-depression and pathological effects during malaria. Phagocytosis of PRBC causes induction of apoptosis in macrophages through release of cytosolic factors from infected cells. Heme polymer or β-hematin causes dose-dependent death of macrophages with...

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Detalles Bibliográficos
Autores principales: Deshmukh, Rohitas, Trivedi, Vishal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117526/
https://www.ncbi.nlm.nih.gov/pubmed/25078090
http://dx.doi.org/10.1371/journal.pone.0103706

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