Cargando…
Phagocytic Uptake of Oxidized Heme Polymer Is Highly Cytotoxic to Macrophages
Apoptosis in macrophages is responsible for immune-depression and pathological effects during malaria. Phagocytosis of PRBC causes induction of apoptosis in macrophages through release of cytosolic factors from infected cells. Heme polymer or β-hematin causes dose-dependent death of macrophages with...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117526/ https://www.ncbi.nlm.nih.gov/pubmed/25078090 http://dx.doi.org/10.1371/journal.pone.0103706 |