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Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors
A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for drugs which alter anxiety-like behavior in ad...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117595/ https://www.ncbi.nlm.nih.gov/pubmed/25079766 http://dx.doi.org/10.1371/journal.pone.0103943 |
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author | Maximino, Caio da Silva, Annanda Waneza Batista Araújo, Juliana Lima, Monica Gomes Miranda, Vanessa Puty, Bruna Benzecry, Rancés Picanço-Diniz, Domingos Luiz Wanderley Gouveia, Amauri Oliveira, Karen Renata Matos Herculano, Anderson Manoel |
author_facet | Maximino, Caio da Silva, Annanda Waneza Batista Araújo, Juliana Lima, Monica Gomes Miranda, Vanessa Puty, Bruna Benzecry, Rancés Picanço-Diniz, Domingos Luiz Wanderley Gouveia, Amauri Oliveira, Karen Renata Matos Herculano, Anderson Manoel |
author_sort | Maximino, Caio |
collection | PubMed |
description | A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for drugs which alter anxiety-like behavior in adult zebrafish. The observed phenotypes were clustered according to shared behavioral effects. This barcoding procedure revealed conserved functions of anxiolytic, anxiogenic and psychomotor stimulating drugs and predicted effects of poorly characterized compounds on anxiety. Moreover, anxiolytic drugs all decreased, while anxiogenic drugs increased, serotonin turnover. These results underscore the power of behavioral profiling in adult zebrafish as an approach which combines throughput and physiological complexity in the pharmacological dissection of complex behaviors. |
format | Online Article Text |
id | pubmed-4117595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-41175952014-08-04 Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors Maximino, Caio da Silva, Annanda Waneza Batista Araújo, Juliana Lima, Monica Gomes Miranda, Vanessa Puty, Bruna Benzecry, Rancés Picanço-Diniz, Domingos Luiz Wanderley Gouveia, Amauri Oliveira, Karen Renata Matos Herculano, Anderson Manoel PLoS One Research Article A major hindrance for the development of psychiatric drugs is the prediction of how treatments can alter complex behaviors in assays which have good throughput and physiological complexity. Here we report the development of a medium-throughput screen for drugs which alter anxiety-like behavior in adult zebrafish. The observed phenotypes were clustered according to shared behavioral effects. This barcoding procedure revealed conserved functions of anxiolytic, anxiogenic and psychomotor stimulating drugs and predicted effects of poorly characterized compounds on anxiety. Moreover, anxiolytic drugs all decreased, while anxiogenic drugs increased, serotonin turnover. These results underscore the power of behavioral profiling in adult zebrafish as an approach which combines throughput and physiological complexity in the pharmacological dissection of complex behaviors. Public Library of Science 2014-07-31 /pmc/articles/PMC4117595/ /pubmed/25079766 http://dx.doi.org/10.1371/journal.pone.0103943 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Maximino, Caio da Silva, Annanda Waneza Batista Araújo, Juliana Lima, Monica Gomes Miranda, Vanessa Puty, Bruna Benzecry, Rancés Picanço-Diniz, Domingos Luiz Wanderley Gouveia, Amauri Oliveira, Karen Renata Matos Herculano, Anderson Manoel Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors |
title | Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors |
title_full | Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors |
title_fullStr | Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors |
title_full_unstemmed | Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors |
title_short | Fingerprinting of Psychoactive Drugs in Zebrafish Anxiety-Like Behaviors |
title_sort | fingerprinting of psychoactive drugs in zebrafish anxiety-like behaviors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117595/ https://www.ncbi.nlm.nih.gov/pubmed/25079766 http://dx.doi.org/10.1371/journal.pone.0103943 |
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