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Fully Human Antagonistic Antibodies against CCR4 Potently Inhibit Cell Signaling and Chemotaxis

BACKGROUND: CC chemokine receptor 4 (CCR4) represents a potentially important target for cancer immunotherapy due to its expression on tumor infiltrating immune cells including regulatory T cells (T(reg)s) and on tumor cells in several cancer types and its role in metastasis. METHODOLOGY: Using phag...

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Detalles Bibliográficos
Autores principales:	Hagemann, Urs B., Gunnarsson, Lavinia, Géraudie, Solène, Scheffler, Ulrike, Griep, Remko A., Reiersen, Herald, Duncan, Alexander R., Kiprijanov, Sergej M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117600/ https://www.ncbi.nlm.nih.gov/pubmed/25080123 http://dx.doi.org/10.1371/journal.pone.0103776

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