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Molecular organization of tricellular tight junctions

When the apicolateral border of epithelial cells is compared with a polygon, its sides correspond to the apical junctional complex, where cell adhesion molecules assemble from the plasma membranes of two adjacent cells. On the other hand, its vertices correspond to tricellular contacts, where the co...

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Autores principales: Furuse, Mikio, Izumi, Yasushi, Oda, Yukako, Higashi, Tomohito, Iwamoto, Noriko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117683/
https://www.ncbi.nlm.nih.gov/pubmed/25097825
http://dx.doi.org/10.4161/tisb.28960
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author Furuse, Mikio
Izumi, Yasushi
Oda, Yukako
Higashi, Tomohito
Iwamoto, Noriko
author_facet Furuse, Mikio
Izumi, Yasushi
Oda, Yukako
Higashi, Tomohito
Iwamoto, Noriko
author_sort Furuse, Mikio
collection PubMed
description When the apicolateral border of epithelial cells is compared with a polygon, its sides correspond to the apical junctional complex, where cell adhesion molecules assemble from the plasma membranes of two adjacent cells. On the other hand, its vertices correspond to tricellular contacts, where the corners of three cells meet. Vertebrate tricellular contacts have specialized structures of tight junctions, termed tricellular tight junctions (tTJs). tTJs were identified by electron microscopic observations more than 40 years ago, but have been largely forgotten in epithelial cell biology since then. The identification of tricellulin and angulin family proteins as tTJ-associated membrane proteins has enabled us to study tTJs in terms of not only the paracellular barrier function but also unknown characteristics of epithelial cell corners via molecular biological approaches.
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spelling pubmed-41176832014-08-05 Molecular organization of tricellular tight junctions Furuse, Mikio Izumi, Yasushi Oda, Yukako Higashi, Tomohito Iwamoto, Noriko Tissue Barriers Review When the apicolateral border of epithelial cells is compared with a polygon, its sides correspond to the apical junctional complex, where cell adhesion molecules assemble from the plasma membranes of two adjacent cells. On the other hand, its vertices correspond to tricellular contacts, where the corners of three cells meet. Vertebrate tricellular contacts have specialized structures of tight junctions, termed tricellular tight junctions (tTJs). tTJs were identified by electron microscopic observations more than 40 years ago, but have been largely forgotten in epithelial cell biology since then. The identification of tricellulin and angulin family proteins as tTJ-associated membrane proteins has enabled us to study tTJs in terms of not only the paracellular barrier function but also unknown characteristics of epithelial cell corners via molecular biological approaches. Landes Bioscience 2014-05-01 /pmc/articles/PMC4117683/ /pubmed/25097825 http://dx.doi.org/10.4161/tisb.28960 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Furuse, Mikio
Izumi, Yasushi
Oda, Yukako
Higashi, Tomohito
Iwamoto, Noriko
Molecular organization of tricellular tight junctions
title Molecular organization of tricellular tight junctions
title_full Molecular organization of tricellular tight junctions
title_fullStr Molecular organization of tricellular tight junctions
title_full_unstemmed Molecular organization of tricellular tight junctions
title_short Molecular organization of tricellular tight junctions
title_sort molecular organization of tricellular tight junctions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117683/
https://www.ncbi.nlm.nih.gov/pubmed/25097825
http://dx.doi.org/10.4161/tisb.28960
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