Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

Genome-wide association studies (GWAS) have identified thousands of loci associated wtih complex traits, but it is challenging to pinpoint causal genes in these loci and to exploit subtle association signals. We used tissue-specific quantitative interaction proteomics to map a network of five genes...

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Detalles Bibliográficos
Autores principales: Lundby, Alicia, Rossin, Elizabeth J., Steffensen, Annette B., Rav Acha, Moshe, Newton-Cheh, Christopher, Pfeufer, Arne, Lynch, Stacey N., Olesen, Søren-Peter, Brunak, Søren, Ellinor, Patrick T., Jukema, J.Wouter, Trompet, Stella, Ford, Ian, Macfarlane, Peter W., Krijthe, Bouwe P., Hofman, Albert, Uitterlinden, Andre G., Stricker, Bruno H., Nathoe, Hendrik M., Spiering, Wilko, Daly, Mark J., Asselbergs, Folkert W., van der Harst, Pim, Milan, David J., de Bakker, Paul I.W., Lage, Kasper, Olsen, Jesper V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117722/
https://www.ncbi.nlm.nih.gov/pubmed/24952909
http://dx.doi.org/10.1038/nmeth.2997

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