Cargando…
Computational detection and suppression of sequence-specific off-target phenotypes from whole genome RNAi screens
A challenge for large-scale siRNA loss-of-function studies is the biological pleiotropy resulting from multiple modes of action of siRNA reagents. A major confounding feature of these reagents is the microRNA-like translational quelling resulting from short regions of oligonucleotide complementarity...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117740/ https://www.ncbi.nlm.nih.gov/pubmed/24972830 http://dx.doi.org/10.1093/nar/gku306 |