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Advances in the pathophysiology of pre-eclampsia and related podocyte injury
Pre-eclampsia is a pregnancy-specific hypertensive disorder that may lead to serious maternal and fetal complications. It is a multisystem disease that is commonly, but not always, accompanied by proteinuria. Its cause(s) remain unknown, and delivery remains the only definitive treatment. It is incr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117806/ https://www.ncbi.nlm.nih.gov/pubmed/24573315 http://dx.doi.org/10.1038/ki.2014.17 |
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author | Craici, Iasmina M. Wagner, Steven J. Weissgerber, Tracey L. Grande, Joseph P. Garovic, Vesna D. |
author_facet | Craici, Iasmina M. Wagner, Steven J. Weissgerber, Tracey L. Grande, Joseph P. Garovic, Vesna D. |
author_sort | Craici, Iasmina M. |
collection | PubMed |
description | Pre-eclampsia is a pregnancy-specific hypertensive disorder that may lead to serious maternal and fetal complications. It is a multisystem disease that is commonly, but not always, accompanied by proteinuria. Its cause(s) remain unknown, and delivery remains the only definitive treatment. It is increasingly recognized that many pathophysiological processes contribute to this syndrome, with different signaling pathways converging at the point of systemic endothelial dysfunction, hypertension, and proteinuria. Different animal models of pre-eclampsia have proven utility for specific aspects of pre-eclampsia research, and offer insights into pathophysiology and treatment possibilities. Therapeutic interventions that specifically target these pathways may optimize pre-eclampsia management and may improve fetal and maternal outcomes. In addition, recent findings regarding placental, endothelial, and podocyte pathophysiology in pre-eclampsia provide unique and exciting possibilities for improved diagnostic accuracy. Emerging evidence suggests that testing for urinary podocytes or their markers may facilitate the prediction and diagnosis of pre-eclampsia. In this review, we explore recent research regarding placental, endothelial, and podocyte pathophysiology. We further discuss new signaling and genetic pathways that may contribute to pre-eclampsia pathophysiology, emerging screening and diagnostic strategies, and potential targeted interventions. |
format | Online Article Text |
id | pubmed-4117806 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
record_format | MEDLINE/PubMed |
spelling | pubmed-41178062015-02-01 Advances in the pathophysiology of pre-eclampsia and related podocyte injury Craici, Iasmina M. Wagner, Steven J. Weissgerber, Tracey L. Grande, Joseph P. Garovic, Vesna D. Kidney Int Article Pre-eclampsia is a pregnancy-specific hypertensive disorder that may lead to serious maternal and fetal complications. It is a multisystem disease that is commonly, but not always, accompanied by proteinuria. Its cause(s) remain unknown, and delivery remains the only definitive treatment. It is increasingly recognized that many pathophysiological processes contribute to this syndrome, with different signaling pathways converging at the point of systemic endothelial dysfunction, hypertension, and proteinuria. Different animal models of pre-eclampsia have proven utility for specific aspects of pre-eclampsia research, and offer insights into pathophysiology and treatment possibilities. Therapeutic interventions that specifically target these pathways may optimize pre-eclampsia management and may improve fetal and maternal outcomes. In addition, recent findings regarding placental, endothelial, and podocyte pathophysiology in pre-eclampsia provide unique and exciting possibilities for improved diagnostic accuracy. Emerging evidence suggests that testing for urinary podocytes or their markers may facilitate the prediction and diagnosis of pre-eclampsia. In this review, we explore recent research regarding placental, endothelial, and podocyte pathophysiology. We further discuss new signaling and genetic pathways that may contribute to pre-eclampsia pathophysiology, emerging screening and diagnostic strategies, and potential targeted interventions. 2014-02-26 2014-08 /pmc/articles/PMC4117806/ /pubmed/24573315 http://dx.doi.org/10.1038/ki.2014.17 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Craici, Iasmina M. Wagner, Steven J. Weissgerber, Tracey L. Grande, Joseph P. Garovic, Vesna D. Advances in the pathophysiology of pre-eclampsia and related podocyte injury |
title | Advances in the pathophysiology of pre-eclampsia and related podocyte injury |
title_full | Advances in the pathophysiology of pre-eclampsia and related podocyte injury |
title_fullStr | Advances in the pathophysiology of pre-eclampsia and related podocyte injury |
title_full_unstemmed | Advances in the pathophysiology of pre-eclampsia and related podocyte injury |
title_short | Advances in the pathophysiology of pre-eclampsia and related podocyte injury |
title_sort | advances in the pathophysiology of pre-eclampsia and related podocyte injury |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117806/ https://www.ncbi.nlm.nih.gov/pubmed/24573315 http://dx.doi.org/10.1038/ki.2014.17 |
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