All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

All-optical electrophysiology—spatially resolved simultaneous optical perturbation and measurement of membrane voltage—would open new vistas in neuroscience research. We evolved two archaerhodopsin-based voltage indicators, QuasAr1 and 2, which show improved brightness and voltage sensitivity, micro...

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Detalles Bibliográficos
Autores principales: Hochbaum, Daniel R., Zhao, Yongxin, Farhi, Samouil L., Klapoetke, Nathan, Werley, Christopher A., Kapoor, Vikrant, Zou, Peng, Kralj, Joel M., Maclaurin, Dougal, Smedemark-Margulies, Niklas, Saulnier, Jessica L., Boulting, Gabriella L., Straub, Christoph, Cho, Yong Ku, Melkonian, Michael, Wong, Gane Ka-Shu, Harrison, D. Jed, Murthy, Venkatesh N., Sabatini, Bernardo, Boyden, Edward S., Campbell, Robert E., Cohen, Adam E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117813/
https://www.ncbi.nlm.nih.gov/pubmed/24952910
http://dx.doi.org/10.1038/nmeth.3000

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