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Effects of Low-Intensity Autonomic Nerve Stimulation on Atrial Electrophysiology

BACKGROUND AND OBJECTIVES: The cardiac autonomic nervous system is an emerging target for therapeutic control of atrial fibrillation (AF). We evaluated the effects of low-intensity autonomic nerve stimulation (LI-ANS) on atrial electrophysiology, AF vulnerability, and neural remodeling. SUBJECTS AND...

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Autores principales: Cho, Youngjin, Cha, Myung-Jin, Choi, Eue-Keun, Oh, Il-Young, Oh, Seil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Cardiology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117845/
https://www.ncbi.nlm.nih.gov/pubmed/25089136
http://dx.doi.org/10.4070/kcj.2014.44.4.243
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author Cho, Youngjin
Cha, Myung-Jin
Choi, Eue-Keun
Oh, Il-Young
Oh, Seil
author_facet Cho, Youngjin
Cha, Myung-Jin
Choi, Eue-Keun
Oh, Il-Young
Oh, Seil
author_sort Cho, Youngjin
collection PubMed
description BACKGROUND AND OBJECTIVES: The cardiac autonomic nervous system is an emerging target for therapeutic control of atrial fibrillation (AF). We evaluated the effects of low-intensity autonomic nerve stimulation (LI-ANS) on atrial electrophysiology, AF vulnerability, and neural remodeling. SUBJECTS AND METHODS: Fourteen dogs were subjected to 3 hours rapid atrial pacing (RAP, 5 Hz) and concomitant high frequency LI-ANS (20 Hz, at voltages 40% below the threshold) as follows: no autonomic stimulation (control, n=3); or right cervical vagus nerve (RVN, n=6), anterior right ganglionated plexi (ARGP, n=3), and superior left ganglionated plexi (SLGP, n=2) stimulation. Programmed and burst atrial pacing were performed at baseline and at the end of each hour to determine atrial effective refractory period (ERP), window of vulnerability (WOV), and inducibility of sustained AF. RESULTS: Atrial ERP was significantly shortened by 3 hours RAP (in control group, ΔERP=-47.9±8.9%, p=0.032), and RAP-induced ERP shortening was attenuated by LI-ANS (in LI-ANS group, ΔERP=-15.4±5.9%, p=0.019; vs. control, p=0.035). Neither WOV for AF nor AF inducibility changed significantly during 3 hours RAP with simultaneous LI-ANS. There was no significant difference between the control and LI-ANS group in nerve density and sprouting evaluated by anti-tyrosine hydroxylase and anti-growth associated protein-43 staining. Among the various sites for LI-ANS, the ARGP-stimulation group showed marginally lower ΔWOV (p=0.077) and lower nerve sprouting (p=0.065) compared to the RVN-stimulation group. CONCLUSION: Low-intensity autonomic nerve stimulation significantly attenuated the shortening of atrial ERP caused by RAP. ARGP may be a better target for LI-ANS than RVN for the purpose of suppressing atrial remodeling in AF.
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spelling pubmed-41178452014-08-01 Effects of Low-Intensity Autonomic Nerve Stimulation on Atrial Electrophysiology Cho, Youngjin Cha, Myung-Jin Choi, Eue-Keun Oh, Il-Young Oh, Seil Korean Circ J Original Article BACKGROUND AND OBJECTIVES: The cardiac autonomic nervous system is an emerging target for therapeutic control of atrial fibrillation (AF). We evaluated the effects of low-intensity autonomic nerve stimulation (LI-ANS) on atrial electrophysiology, AF vulnerability, and neural remodeling. SUBJECTS AND METHODS: Fourteen dogs were subjected to 3 hours rapid atrial pacing (RAP, 5 Hz) and concomitant high frequency LI-ANS (20 Hz, at voltages 40% below the threshold) as follows: no autonomic stimulation (control, n=3); or right cervical vagus nerve (RVN, n=6), anterior right ganglionated plexi (ARGP, n=3), and superior left ganglionated plexi (SLGP, n=2) stimulation. Programmed and burst atrial pacing were performed at baseline and at the end of each hour to determine atrial effective refractory period (ERP), window of vulnerability (WOV), and inducibility of sustained AF. RESULTS: Atrial ERP was significantly shortened by 3 hours RAP (in control group, ΔERP=-47.9±8.9%, p=0.032), and RAP-induced ERP shortening was attenuated by LI-ANS (in LI-ANS group, ΔERP=-15.4±5.9%, p=0.019; vs. control, p=0.035). Neither WOV for AF nor AF inducibility changed significantly during 3 hours RAP with simultaneous LI-ANS. There was no significant difference between the control and LI-ANS group in nerve density and sprouting evaluated by anti-tyrosine hydroxylase and anti-growth associated protein-43 staining. Among the various sites for LI-ANS, the ARGP-stimulation group showed marginally lower ΔWOV (p=0.077) and lower nerve sprouting (p=0.065) compared to the RVN-stimulation group. CONCLUSION: Low-intensity autonomic nerve stimulation significantly attenuated the shortening of atrial ERP caused by RAP. ARGP may be a better target for LI-ANS than RVN for the purpose of suppressing atrial remodeling in AF. The Korean Society of Cardiology 2014-07 2014-07-25 /pmc/articles/PMC4117845/ /pubmed/25089136 http://dx.doi.org/10.4070/kcj.2014.44.4.243 Text en Copyright © 2014 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cho, Youngjin
Cha, Myung-Jin
Choi, Eue-Keun
Oh, Il-Young
Oh, Seil
Effects of Low-Intensity Autonomic Nerve Stimulation on Atrial Electrophysiology
title Effects of Low-Intensity Autonomic Nerve Stimulation on Atrial Electrophysiology
title_full Effects of Low-Intensity Autonomic Nerve Stimulation on Atrial Electrophysiology
title_fullStr Effects of Low-Intensity Autonomic Nerve Stimulation on Atrial Electrophysiology
title_full_unstemmed Effects of Low-Intensity Autonomic Nerve Stimulation on Atrial Electrophysiology
title_short Effects of Low-Intensity Autonomic Nerve Stimulation on Atrial Electrophysiology
title_sort effects of low-intensity autonomic nerve stimulation on atrial electrophysiology
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117845/
https://www.ncbi.nlm.nih.gov/pubmed/25089136
http://dx.doi.org/10.4070/kcj.2014.44.4.243
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