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Revascularization for Patients with Idiopathic Thrombocytopenic Purpura and Coronary Artery Disease
Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder with a low platelet count characterized by premature platelet destruction and suppression of platelet production mediated by autoantibodies, which may predispose to bleeding. Although the prevalence of coronary artery disease (CAD)...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Cardiology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117848/ https://www.ncbi.nlm.nih.gov/pubmed/25089139 http://dx.doi.org/10.4070/kcj.2014.44.4.264 |
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author | Lee, Chan-Hee Kim, Ung |
author_facet | Lee, Chan-Hee Kim, Ung |
author_sort | Lee, Chan-Hee |
collection | PubMed |
description | Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder with a low platelet count characterized by premature platelet destruction and suppression of platelet production mediated by autoantibodies, which may predispose to bleeding. Although the prevalence of coronary artery disease (CAD) in ITP seems to be rare, their co-occurrence is not unusual. Patients with ITP have increased risks for thrombosis and atherosclerosis associated with hemostatic factors, endothelial damage, and the negative effects of steroid and immunoglobulin therapies. Thus, the coexistence of ITP and CAD presents complex problems requiring a balance between hemorrhagic risk and prevention of thrombosis. Here, the authors present two patients with ITP, who were revascularized in different ways for CAD. Although the optimal management of thrombocytopenic patients with CAD is uncertain, individualized treatment modalities can be useful in patients with ITP and CAD. |
format | Online Article Text |
id | pubmed-4117848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Korean Society of Cardiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-41178482014-08-01 Revascularization for Patients with Idiopathic Thrombocytopenic Purpura and Coronary Artery Disease Lee, Chan-Hee Kim, Ung Korean Circ J Case Report Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder with a low platelet count characterized by premature platelet destruction and suppression of platelet production mediated by autoantibodies, which may predispose to bleeding. Although the prevalence of coronary artery disease (CAD) in ITP seems to be rare, their co-occurrence is not unusual. Patients with ITP have increased risks for thrombosis and atherosclerosis associated with hemostatic factors, endothelial damage, and the negative effects of steroid and immunoglobulin therapies. Thus, the coexistence of ITP and CAD presents complex problems requiring a balance between hemorrhagic risk and prevention of thrombosis. Here, the authors present two patients with ITP, who were revascularized in different ways for CAD. Although the optimal management of thrombocytopenic patients with CAD is uncertain, individualized treatment modalities can be useful in patients with ITP and CAD. The Korean Society of Cardiology 2014-07 2014-07-25 /pmc/articles/PMC4117848/ /pubmed/25089139 http://dx.doi.org/10.4070/kcj.2014.44.4.264 Text en Copyright © 2014 The Korean Society of Cardiology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Lee, Chan-Hee Kim, Ung Revascularization for Patients with Idiopathic Thrombocytopenic Purpura and Coronary Artery Disease |
title | Revascularization for Patients with Idiopathic Thrombocytopenic Purpura and Coronary Artery Disease |
title_full | Revascularization for Patients with Idiopathic Thrombocytopenic Purpura and Coronary Artery Disease |
title_fullStr | Revascularization for Patients with Idiopathic Thrombocytopenic Purpura and Coronary Artery Disease |
title_full_unstemmed | Revascularization for Patients with Idiopathic Thrombocytopenic Purpura and Coronary Artery Disease |
title_short | Revascularization for Patients with Idiopathic Thrombocytopenic Purpura and Coronary Artery Disease |
title_sort | revascularization for patients with idiopathic thrombocytopenic purpura and coronary artery disease |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117848/ https://www.ncbi.nlm.nih.gov/pubmed/25089139 http://dx.doi.org/10.4070/kcj.2014.44.4.264 |
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