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Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications
In healthy individuals, billions of cells die by apoptosis every day. Removal of the dead cells by phagocytosis (a process called efferocytosis) must be efficient to prevent secondary necrosis and the consequent release of pro-inflammatory cell contents that damages the tissue environment and provok...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117929/ https://www.ncbi.nlm.nih.gov/pubmed/25136342 http://dx.doi.org/10.3389/fimmu.2014.00354 |
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author | Szondy, Zsuzsa Garabuczi, Éva Joós, Gergely Tsay, Gregory J. Sarang, Zsolt |
author_facet | Szondy, Zsuzsa Garabuczi, Éva Joós, Gergely Tsay, Gregory J. Sarang, Zsolt |
author_sort | Szondy, Zsuzsa |
collection | PubMed |
description | In healthy individuals, billions of cells die by apoptosis every day. Removal of the dead cells by phagocytosis (a process called efferocytosis) must be efficient to prevent secondary necrosis and the consequent release of pro-inflammatory cell contents that damages the tissue environment and provokes autoimmunity. In addition, detection and removal of apoptotic cells generally induces an anti-inflammatory response. As a consequence improper clearance of apoptotic cells, being the result of either genetic anomalies and/or a persistent disease state, contributes to the establishment and progression of a number of human chronic inflammatory diseases such as autoimmune and neurological disorders, inflammatory lung diseases, obesity, type 2 diabetes, or atherosclerosis. During the past decade, our knowledge about the mechanism of efferocytosis has significantly increased, providing therapeutic targets through which impaired phagocytosis of apoptotic cells and the consequent inflammation could be influenced in these diseases. |
format | Online Article Text |
id | pubmed-4117929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41179292014-08-18 Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications Szondy, Zsuzsa Garabuczi, Éva Joós, Gergely Tsay, Gregory J. Sarang, Zsolt Front Immunol Immunology In healthy individuals, billions of cells die by apoptosis every day. Removal of the dead cells by phagocytosis (a process called efferocytosis) must be efficient to prevent secondary necrosis and the consequent release of pro-inflammatory cell contents that damages the tissue environment and provokes autoimmunity. In addition, detection and removal of apoptotic cells generally induces an anti-inflammatory response. As a consequence improper clearance of apoptotic cells, being the result of either genetic anomalies and/or a persistent disease state, contributes to the establishment and progression of a number of human chronic inflammatory diseases such as autoimmune and neurological disorders, inflammatory lung diseases, obesity, type 2 diabetes, or atherosclerosis. During the past decade, our knowledge about the mechanism of efferocytosis has significantly increased, providing therapeutic targets through which impaired phagocytosis of apoptotic cells and the consequent inflammation could be influenced in these diseases. Frontiers Media S.A. 2014-08-01 /pmc/articles/PMC4117929/ /pubmed/25136342 http://dx.doi.org/10.3389/fimmu.2014.00354 Text en Copyright © 2014 Szondy, Garabuczi, Joós, Tsay and Sarang. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Szondy, Zsuzsa Garabuczi, Éva Joós, Gergely Tsay, Gregory J. Sarang, Zsolt Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications |
title | Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications |
title_full | Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications |
title_fullStr | Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications |
title_full_unstemmed | Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications |
title_short | Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications |
title_sort | impaired clearance of apoptotic cells in chronic inflammatory diseases: therapeutic implications |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117929/ https://www.ncbi.nlm.nih.gov/pubmed/25136342 http://dx.doi.org/10.3389/fimmu.2014.00354 |
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