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Congenital heart malformations induced by hemodynamic altering surgical interventions
Embryonic heart formation results from a dynamic interplay between genetic and environmental factors. Blood flow during early embryonic stages plays a critical role in heart development, as interactions between flow and cardiac tissues generate biomechanical forces that modulate cardiac growth and r...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117980/ https://www.ncbi.nlm.nih.gov/pubmed/25136319 http://dx.doi.org/10.3389/fphys.2014.00287 |
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author | Midgett, Madeline Rugonyi, Sandra |
author_facet | Midgett, Madeline Rugonyi, Sandra |
author_sort | Midgett, Madeline |
collection | PubMed |
description | Embryonic heart formation results from a dynamic interplay between genetic and environmental factors. Blood flow during early embryonic stages plays a critical role in heart development, as interactions between flow and cardiac tissues generate biomechanical forces that modulate cardiac growth and remodeling. Normal hemodynamic conditions are essential for proper cardiac development, while altered blood flow induced by surgical manipulations in animal models result in heart defects similar to those seen in humans with congenital heart disease. This review compares the altered hemodynamics, changes in tissue properties, and cardiac defects reported after common surgical interventions that alter hemodynamics in the early chick embryo, and shows that interventions produce a wide spectrum of cardiac defects. Vitelline vein ligation and left atrial ligation decrease blood pressure and flow; and outflow tract banding increases blood pressure and flow velocities. These three surgical interventions result in many of the same cardiac defects, which indicate that the altered hemodynamics interfere with common looping, septation and valve formation processes that occur after intervention and that shape the four-chambered heart. While many similar defects develop after the interventions, the varying degrees of hemodynamic load alteration among the three interventions also result in varying incidence and severity of cardiac defects, indicating that the hemodynamic modulation of cardiac developmental processes is strongly dependent on hemodynamic load. |
format | Online Article Text |
id | pubmed-4117980 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-41179802014-08-18 Congenital heart malformations induced by hemodynamic altering surgical interventions Midgett, Madeline Rugonyi, Sandra Front Physiol Physics Embryonic heart formation results from a dynamic interplay between genetic and environmental factors. Blood flow during early embryonic stages plays a critical role in heart development, as interactions between flow and cardiac tissues generate biomechanical forces that modulate cardiac growth and remodeling. Normal hemodynamic conditions are essential for proper cardiac development, while altered blood flow induced by surgical manipulations in animal models result in heart defects similar to those seen in humans with congenital heart disease. This review compares the altered hemodynamics, changes in tissue properties, and cardiac defects reported after common surgical interventions that alter hemodynamics in the early chick embryo, and shows that interventions produce a wide spectrum of cardiac defects. Vitelline vein ligation and left atrial ligation decrease blood pressure and flow; and outflow tract banding increases blood pressure and flow velocities. These three surgical interventions result in many of the same cardiac defects, which indicate that the altered hemodynamics interfere with common looping, septation and valve formation processes that occur after intervention and that shape the four-chambered heart. While many similar defects develop after the interventions, the varying degrees of hemodynamic load alteration among the three interventions also result in varying incidence and severity of cardiac defects, indicating that the hemodynamic modulation of cardiac developmental processes is strongly dependent on hemodynamic load. Frontiers Media S.A. 2014-08-01 /pmc/articles/PMC4117980/ /pubmed/25136319 http://dx.doi.org/10.3389/fphys.2014.00287 Text en Copyright © 2014 Midgett and Rugonyi. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physics Midgett, Madeline Rugonyi, Sandra Congenital heart malformations induced by hemodynamic altering surgical interventions |
title | Congenital heart malformations induced by hemodynamic altering surgical interventions |
title_full | Congenital heart malformations induced by hemodynamic altering surgical interventions |
title_fullStr | Congenital heart malformations induced by hemodynamic altering surgical interventions |
title_full_unstemmed | Congenital heart malformations induced by hemodynamic altering surgical interventions |
title_short | Congenital heart malformations induced by hemodynamic altering surgical interventions |
title_sort | congenital heart malformations induced by hemodynamic altering surgical interventions |
topic | Physics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117980/ https://www.ncbi.nlm.nih.gov/pubmed/25136319 http://dx.doi.org/10.3389/fphys.2014.00287 |
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