Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance

We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American–Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison wi...

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Detalles Bibliográficos
Autores principales: Guio, H., Tarazona, D., Galarza, M., Borda, V., Curitomay, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118072/
https://www.ncbi.nlm.nih.gov/pubmed/25081269
http://dx.doi.org/10.1128/genomeA.00759-14
Descripción
Sumario:We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American–Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.

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