Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance

We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American–Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison wi...

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Autores principales: Guio, H., Tarazona, D., Galarza, M., Borda, V., Curitomay, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118072/
https://www.ncbi.nlm.nih.gov/pubmed/25081269
http://dx.doi.org/10.1128/genomeA.00759-14
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author Guio, H.
Tarazona, D.
Galarza, M.
Borda, V.
Curitomay, R.
author_facet Guio, H.
Tarazona, D.
Galarza, M.
Borda, V.
Curitomay, R.
author_sort Guio, H.
collection PubMed
description We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American–Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance.
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spelling pubmed-41180722014-08-08 Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance Guio, H. Tarazona, D. Galarza, M. Borda, V. Curitomay, R. Genome Announc Prokaryotes We report the whole-genome sequence of an extensively drug-resistant (XDR) tuberculosis (TB) strain of Latin American–Mediterranean (LAM) lineage. This strain is phenotypically resistant to aminoglycosides, but carries no related mutations in rrs, tlyA, and eis. Through genome analysis comparison with 16 XDR strains, we found 218 non-synonymous single nucleotide polymorphisms (SNPs) shared that could confer resistance. American Society for Microbiology 2014-07-31 /pmc/articles/PMC4118072/ /pubmed/25081269 http://dx.doi.org/10.1128/genomeA.00759-14 Text en Copyright © 2014 Guio et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Prokaryotes
Guio, H.
Tarazona, D.
Galarza, M.
Borda, V.
Curitomay, R.
Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance
title Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance
title_full Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance
title_fullStr Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance
title_full_unstemmed Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance
title_short Genome Analysis of 17 Extensively Drug-Resistant Strains Reveals New Potential Mutations for Resistance
title_sort genome analysis of 17 extensively drug-resistant strains reveals new potential mutations for resistance
topic Prokaryotes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118072/
https://www.ncbi.nlm.nih.gov/pubmed/25081269
http://dx.doi.org/10.1128/genomeA.00759-14
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