Cancer, stem cell misplacement and cancer stem cells

The cell of origin of cancer as well as cancer stem cells is still a mystery. In a recent issue of JCMM, Wang et al. challenged the conventional somatic genetic mutation model of multi-stage carcinogenesis of breast cancer and proposed that ‘Invasive cancers are not necessary from preformed in situ...

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Detalles Bibliográficos
Autor principal: Liao, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118178/
https://www.ncbi.nlm.nih.gov/pubmed/23855541
http://dx.doi.org/10.1111/jcmm.12104
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author Liao, Yong
author_facet Liao, Yong
author_sort Liao, Yong
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description The cell of origin of cancer as well as cancer stem cells is still a mystery. In a recent issue of JCMM, Wang et al. challenged the conventional somatic genetic mutation model of multi-stage carcinogenesis of breast cancer and proposed that ‘Invasive cancers are not necessary from preformed in situ tumours—an alternative way of carcinogenesis from misplaced stem cells’. If this stem cell misplacement theory could withstand future experimental evaluation, it may provide a paradigm shift in the prevention and management of cancer in the clinic.
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spelling pubmed-41181782014-12-03 Cancer, stem cell misplacement and cancer stem cells Liao, Yong J Cell Mol Med Commentary The cell of origin of cancer as well as cancer stem cells is still a mystery. In a recent issue of JCMM, Wang et al. challenged the conventional somatic genetic mutation model of multi-stage carcinogenesis of breast cancer and proposed that ‘Invasive cancers are not necessary from preformed in situ tumours—an alternative way of carcinogenesis from misplaced stem cells’. If this stem cell misplacement theory could withstand future experimental evaluation, it may provide a paradigm shift in the prevention and management of cancer in the clinic. Blackwell Publishing Ltd 2013-09 2013-07-16 /pmc/articles/PMC4118178/ /pubmed/23855541 http://dx.doi.org/10.1111/jcmm.12104 Text en © 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Commentary
Liao, Yong
Cancer, stem cell misplacement and cancer stem cells
title Cancer, stem cell misplacement and cancer stem cells
title_full Cancer, stem cell misplacement and cancer stem cells
title_fullStr Cancer, stem cell misplacement and cancer stem cells
title_full_unstemmed Cancer, stem cell misplacement and cancer stem cells
title_short Cancer, stem cell misplacement and cancer stem cells
title_sort cancer, stem cell misplacement and cancer stem cells
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118178/
https://www.ncbi.nlm.nih.gov/pubmed/23855541
http://dx.doi.org/10.1111/jcmm.12104
work_keys_str_mv AT liaoyong cancerstemcellmisplacementandcancerstemcells

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