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Early menarche and childhood adversities in a nationally representative sample
BACKGROUND: Epidemiological evidence suggests that early menarche, defined as onset of menses at age 11 or earlier, has increased in prevalence in recent birth cohorts and is associated with multiple poor medical and mental health outcomes in adulthood. There is evidence that childhood adversities o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118267/ https://www.ncbi.nlm.nih.gov/pubmed/25089128 http://dx.doi.org/10.1186/1687-9856-2014-14 |
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author | Henrichs, Kimberly L McCauley, Heather L Miller, Elizabeth Styne, Dennis M Saito, Naomi Breslau, Joshua |
author_facet | Henrichs, Kimberly L McCauley, Heather L Miller, Elizabeth Styne, Dennis M Saito, Naomi Breslau, Joshua |
author_sort | Henrichs, Kimberly L |
collection | PubMed |
description | BACKGROUND: Epidemiological evidence suggests that early menarche, defined as onset of menses at age 11 or earlier, has increased in prevalence in recent birth cohorts and is associated with multiple poor medical and mental health outcomes in adulthood. There is evidence that childhood adversities occurring prior to menarche contribute to early menarche. METHODS: Data collected in face-to-face interviews with a nationally representative sample of women age 18 and over (N = 3288), as part of the National Comorbidity Survey-Replication, were analyzed. Associations between pre-menarchal childhood adversities and menarche at age 11 or earlier were estimated in discrete time survival models with statistical adjustment for age at interview, ethnicity, and body mass index. Adversities investigated included physical abuse, sexual abuse, neglect, biological father absence from the home, other parent loss, parent mental illness, parent substance abuse, parent criminality, inter-parental violence, serious physical illness in childhood, and family economic adversity. RESULTS: Mean age at menarche varied across decadal birth cohorts (χ(2)₍₄₎ = 21.41, p < .001) ranging from a high of 12.9 years in the oldest cohort (age 59 or older at the time of interview) to a low of 12.4 in the second youngest cohort (age 28-37). Childhood adversities were also more common in younger than older cohorts. Of the 11 childhood adversities, 5 were associated with menarche at age 11 or earlier, with OR of 1.3 or greater. Each of these five adversities is associated with a 26% increase in the odds of early menarche (OR = 1.26, 95% CI 1.14-1.39). The relationship between childhood sexual abuse and early menarche was sustained after adjustment for co-occurring adversities. (OR = 1.77, 95% CI 1.21-2.6). CONCLUSIONS: Evidence from this study is consistent with hypothesized physiological effects of early childhood family environment on endocrine development. Childhood sexual abuse is the adversity most strongly associated with early menarche. However, because of the complex way that childhood adversities cluster within families, the more generalized influence of highly dysfunctional family environments cannot be ruled out. |
format | Online Article Text |
id | pubmed-4118267 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-41182672014-08-02 Early menarche and childhood adversities in a nationally representative sample Henrichs, Kimberly L McCauley, Heather L Miller, Elizabeth Styne, Dennis M Saito, Naomi Breslau, Joshua Int J Pediatr Endocrinol Research BACKGROUND: Epidemiological evidence suggests that early menarche, defined as onset of menses at age 11 or earlier, has increased in prevalence in recent birth cohorts and is associated with multiple poor medical and mental health outcomes in adulthood. There is evidence that childhood adversities occurring prior to menarche contribute to early menarche. METHODS: Data collected in face-to-face interviews with a nationally representative sample of women age 18 and over (N = 3288), as part of the National Comorbidity Survey-Replication, were analyzed. Associations between pre-menarchal childhood adversities and menarche at age 11 or earlier were estimated in discrete time survival models with statistical adjustment for age at interview, ethnicity, and body mass index. Adversities investigated included physical abuse, sexual abuse, neglect, biological father absence from the home, other parent loss, parent mental illness, parent substance abuse, parent criminality, inter-parental violence, serious physical illness in childhood, and family economic adversity. RESULTS: Mean age at menarche varied across decadal birth cohorts (χ(2)₍₄₎ = 21.41, p < .001) ranging from a high of 12.9 years in the oldest cohort (age 59 or older at the time of interview) to a low of 12.4 in the second youngest cohort (age 28-37). Childhood adversities were also more common in younger than older cohorts. Of the 11 childhood adversities, 5 were associated with menarche at age 11 or earlier, with OR of 1.3 or greater. Each of these five adversities is associated with a 26% increase in the odds of early menarche (OR = 1.26, 95% CI 1.14-1.39). The relationship between childhood sexual abuse and early menarche was sustained after adjustment for co-occurring adversities. (OR = 1.77, 95% CI 1.21-2.6). CONCLUSIONS: Evidence from this study is consistent with hypothesized physiological effects of early childhood family environment on endocrine development. Childhood sexual abuse is the adversity most strongly associated with early menarche. However, because of the complex way that childhood adversities cluster within families, the more generalized influence of highly dysfunctional family environments cannot be ruled out. BioMed Central 2014 2014-07-15 /pmc/articles/PMC4118267/ /pubmed/25089128 http://dx.doi.org/10.1186/1687-9856-2014-14 Text en Copyright © 2014 Henrichs et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Henrichs, Kimberly L McCauley, Heather L Miller, Elizabeth Styne, Dennis M Saito, Naomi Breslau, Joshua Early menarche and childhood adversities in a nationally representative sample |
title | Early menarche and childhood adversities in a nationally representative sample |
title_full | Early menarche and childhood adversities in a nationally representative sample |
title_fullStr | Early menarche and childhood adversities in a nationally representative sample |
title_full_unstemmed | Early menarche and childhood adversities in a nationally representative sample |
title_short | Early menarche and childhood adversities in a nationally representative sample |
title_sort | early menarche and childhood adversities in a nationally representative sample |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118267/ https://www.ncbi.nlm.nih.gov/pubmed/25089128 http://dx.doi.org/10.1186/1687-9856-2014-14 |
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