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Acute encephalitis syndrome following scrub typhus infection
OBJECTIVE: The aim was to find the incidence of acute encephalitis syndrome (AES) secondary to scrub infection and to observe the clinical, biochemical, radiological profile, and outcomes in these patients. MATERIALS AND METHODS: A total of 20 consecutive patients of AES were evaluated for scrub inf...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118511/ https://www.ncbi.nlm.nih.gov/pubmed/25097358 http://dx.doi.org/10.4103/0972-5229.136074 |
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author | Kar, Ayan Dhanaraj, M. Dedeepiya, Devaprasad Harikrishna, K. |
author_facet | Kar, Ayan Dhanaraj, M. Dedeepiya, Devaprasad Harikrishna, K. |
author_sort | Kar, Ayan |
collection | PubMed |
description | OBJECTIVE: The aim was to find the incidence of acute encephalitis syndrome (AES) secondary to scrub infection and to observe the clinical, biochemical, radiological profile, and outcomes in these patients. MATERIALS AND METHODS: A total of 20 consecutive patients of AES were evaluated for scrub infection using scrub typhus immunoglobulin M enzyme linked immuno-sorbant assay positivity along with the presence or absence of an eschar. Clinical profile, routine laboratory tests, cerebrospinal fluid (CSF) analysis, and neuroimaging were analyzed. Patients were treated with doxycycline and followed-up. RESULTS: Among 20 consecutive patients with AES, 6 (30%) were due to scrub infection. They presented with acute onset fever, altered sensorium, seizures. Eschar was seen in 50% of patients. CSF done in two of them was similar to consistent with viral meningitis. Magnetic resonance imaging brain revealed cerebral edema, bright lesions in the putamen and the thalamus on T2-weighted and fluid-attenuated inversion recovery sequences. Renal involvement was seen in all patients. All patients responded well to oral doxycycline. CONCLUSION: AES is not an uncommon neurological presentation following scrub typhus infection. It should be suspected in all patients with fever, altered sensorium, and renal involvement. Oral doxycycline should be started as early as possible for better outcomes. |
format | Online Article Text |
id | pubmed-4118511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-41185112014-08-05 Acute encephalitis syndrome following scrub typhus infection Kar, Ayan Dhanaraj, M. Dedeepiya, Devaprasad Harikrishna, K. Indian J Crit Care Med Brief Communication OBJECTIVE: The aim was to find the incidence of acute encephalitis syndrome (AES) secondary to scrub infection and to observe the clinical, biochemical, radiological profile, and outcomes in these patients. MATERIALS AND METHODS: A total of 20 consecutive patients of AES were evaluated for scrub infection using scrub typhus immunoglobulin M enzyme linked immuno-sorbant assay positivity along with the presence or absence of an eschar. Clinical profile, routine laboratory tests, cerebrospinal fluid (CSF) analysis, and neuroimaging were analyzed. Patients were treated with doxycycline and followed-up. RESULTS: Among 20 consecutive patients with AES, 6 (30%) were due to scrub infection. They presented with acute onset fever, altered sensorium, seizures. Eschar was seen in 50% of patients. CSF done in two of them was similar to consistent with viral meningitis. Magnetic resonance imaging brain revealed cerebral edema, bright lesions in the putamen and the thalamus on T2-weighted and fluid-attenuated inversion recovery sequences. Renal involvement was seen in all patients. All patients responded well to oral doxycycline. CONCLUSION: AES is not an uncommon neurological presentation following scrub typhus infection. It should be suspected in all patients with fever, altered sensorium, and renal involvement. Oral doxycycline should be started as early as possible for better outcomes. Medknow Publications & Media Pvt Ltd 2014-07 /pmc/articles/PMC4118511/ /pubmed/25097358 http://dx.doi.org/10.4103/0972-5229.136074 Text en Copyright: © Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Brief Communication Kar, Ayan Dhanaraj, M. Dedeepiya, Devaprasad Harikrishna, K. Acute encephalitis syndrome following scrub typhus infection |
title | Acute encephalitis syndrome following scrub typhus infection |
title_full | Acute encephalitis syndrome following scrub typhus infection |
title_fullStr | Acute encephalitis syndrome following scrub typhus infection |
title_full_unstemmed | Acute encephalitis syndrome following scrub typhus infection |
title_short | Acute encephalitis syndrome following scrub typhus infection |
title_sort | acute encephalitis syndrome following scrub typhus infection |
topic | Brief Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118511/ https://www.ncbi.nlm.nih.gov/pubmed/25097358 http://dx.doi.org/10.4103/0972-5229.136074 |
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