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Effect of ethanolic extract of Lepidium meyenii Walp on serum hormone levels in ovariectomized rats

OBJECTIVE: To evaluate the effect of long-term ethanol extract of Lepidium meyenii (Maca) on serum hormone levels in ovariectomized (OVX) rats and compare them with the effect of diethylstilbestrol. MATERIALS AND METHODS: Fifty female Sprague-Dawley rats were ovariectomized or sham operated. Both sh...

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Autores principales: Zhang, Yongzhong, Yu, Longjiang, Jin, Wenwen, Ao, Mingzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118536/
https://www.ncbi.nlm.nih.gov/pubmed/25097281
http://dx.doi.org/10.4103/0253-7613.135955
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author Zhang, Yongzhong
Yu, Longjiang
Jin, Wenwen
Ao, Mingzhang
author_facet Zhang, Yongzhong
Yu, Longjiang
Jin, Wenwen
Ao, Mingzhang
author_sort Zhang, Yongzhong
collection PubMed
description OBJECTIVE: To evaluate the effect of long-term ethanol extract of Lepidium meyenii (Maca) on serum hormone levels in ovariectomized (OVX) rats and compare them with the effect of diethylstilbestrol. MATERIALS AND METHODS: Fifty female Sprague-Dawley rats were ovariectomized or sham operated. Both sham and OVX control groups (n = 10, respectively) received the vehicle. The remaining OVX rats were oral administrated with ethanol extract of Maca (0.096, or 0.24g/kg; n = 10, respectively) and diethylstilbestrol (0.05 mg/kg; n = 10). The treatment continued for 28 weeks. At week 12 and week 28, the blood of rats was collected and serum hormone levels, including estradiol (E2), testosterone (T) and follicle-stimulating hormone (FSH) were measured by radioimmunoassay. RESULTS: At week 12, the levels of serum E2 were slightly higher in Maca groups than that in OVX group; T levels were significantly decreased; and FSH levels were advanced slightly in Maca groups than that in sham group. After 28 weeks administration, serum E2 levels in Maca-treated animals did not differ significantly from sham control, the low dose of Maca increased serum E2 levels, and Maca prevented increase in serum FSH levels compared with OVX group. CONCLUSIONS: Long-term Maca supply modulates endocrine hormone balance in OVX rats, especially it decreases enhanced FSH levels. It is proposed that Maca may become a potential choice for postmenopausal women.
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spelling pubmed-41185362014-08-05 Effect of ethanolic extract of Lepidium meyenii Walp on serum hormone levels in ovariectomized rats Zhang, Yongzhong Yu, Longjiang Jin, Wenwen Ao, Mingzhang Indian J Pharmacol Research Article OBJECTIVE: To evaluate the effect of long-term ethanol extract of Lepidium meyenii (Maca) on serum hormone levels in ovariectomized (OVX) rats and compare them with the effect of diethylstilbestrol. MATERIALS AND METHODS: Fifty female Sprague-Dawley rats were ovariectomized or sham operated. Both sham and OVX control groups (n = 10, respectively) received the vehicle. The remaining OVX rats were oral administrated with ethanol extract of Maca (0.096, or 0.24g/kg; n = 10, respectively) and diethylstilbestrol (0.05 mg/kg; n = 10). The treatment continued for 28 weeks. At week 12 and week 28, the blood of rats was collected and serum hormone levels, including estradiol (E2), testosterone (T) and follicle-stimulating hormone (FSH) were measured by radioimmunoassay. RESULTS: At week 12, the levels of serum E2 were slightly higher in Maca groups than that in OVX group; T levels were significantly decreased; and FSH levels were advanced slightly in Maca groups than that in sham group. After 28 weeks administration, serum E2 levels in Maca-treated animals did not differ significantly from sham control, the low dose of Maca increased serum E2 levels, and Maca prevented increase in serum FSH levels compared with OVX group. CONCLUSIONS: Long-term Maca supply modulates endocrine hormone balance in OVX rats, especially it decreases enhanced FSH levels. It is proposed that Maca may become a potential choice for postmenopausal women. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4118536/ /pubmed/25097281 http://dx.doi.org/10.4103/0253-7613.135955 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Yongzhong
Yu, Longjiang
Jin, Wenwen
Ao, Mingzhang
Effect of ethanolic extract of Lepidium meyenii Walp on serum hormone levels in ovariectomized rats
title Effect of ethanolic extract of Lepidium meyenii Walp on serum hormone levels in ovariectomized rats
title_full Effect of ethanolic extract of Lepidium meyenii Walp on serum hormone levels in ovariectomized rats
title_fullStr Effect of ethanolic extract of Lepidium meyenii Walp on serum hormone levels in ovariectomized rats
title_full_unstemmed Effect of ethanolic extract of Lepidium meyenii Walp on serum hormone levels in ovariectomized rats
title_short Effect of ethanolic extract of Lepidium meyenii Walp on serum hormone levels in ovariectomized rats
title_sort effect of ethanolic extract of lepidium meyenii walp on serum hormone levels in ovariectomized rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118536/
https://www.ncbi.nlm.nih.gov/pubmed/25097281
http://dx.doi.org/10.4103/0253-7613.135955
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