Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro

OBJECTIVES: To investigate the antiplatelet activity of alpha-lipoic acid (α-LA) and dihydroquercetin (DHQ). MATERIALS AND: Methods: Antiplatelet activity of the α-LA and DHQ was evaluated in rich platelet plasma of rat. The platelet aggregation was induced by adenosine diphosphate (ADP) in concentr...

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Autores principales: Ivanov, Ivan S., Sidehmenova, Anastasia V., Smol’yakova, Vera I., Chernysheva, Galina A., Plotnikov, Mark B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118539/
https://www.ncbi.nlm.nih.gov/pubmed/25097284
http://dx.doi.org/10.4103/0253-7613.135958
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author Ivanov, Ivan S.
Sidehmenova, Anastasia V.
Smol’yakova, Vera I.
Chernysheva, Galina A.
Plotnikov, Mark B.
author_facet Ivanov, Ivan S.
Sidehmenova, Anastasia V.
Smol’yakova, Vera I.
Chernysheva, Galina A.
Plotnikov, Mark B.
author_sort Ivanov, Ivan S.
collection PubMed
description OBJECTIVES: To investigate the antiplatelet activity of alpha-lipoic acid (α-LA) and dihydroquercetin (DHQ). MATERIALS AND: Methods: Antiplatelet activity of the α-LA and DHQ was evaluated in rich platelet plasma of rat. The platelet aggregation was induced by adenosine diphosphate (ADP) in concentration of 4 × 10(-5) M. RESULTS: α-LA and DHQ inhibited platelet aggregation in concentration-dependent manner. The antiplatelet activity of α-LA was more pronounced than DHQ. DHQ also increased the antiplatelet activity of α-LA by 1.4 times. CONCLUSION: Combined simultaneous use of α-LA and DHQ possessed the high antiplatelet activity, and DHQ potentiated the activity of α-LA.
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spelling pubmed-41185392014-08-05 Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro Ivanov, Ivan S. Sidehmenova, Anastasia V. Smol’yakova, Vera I. Chernysheva, Galina A. Plotnikov, Mark B. Indian J Pharmacol Short Communication OBJECTIVES: To investigate the antiplatelet activity of alpha-lipoic acid (α-LA) and dihydroquercetin (DHQ). MATERIALS AND: Methods: Antiplatelet activity of the α-LA and DHQ was evaluated in rich platelet plasma of rat. The platelet aggregation was induced by adenosine diphosphate (ADP) in concentration of 4 × 10(-5) M. RESULTS: α-LA and DHQ inhibited platelet aggregation in concentration-dependent manner. The antiplatelet activity of α-LA was more pronounced than DHQ. DHQ also increased the antiplatelet activity of α-LA by 1.4 times. CONCLUSION: Combined simultaneous use of α-LA and DHQ possessed the high antiplatelet activity, and DHQ potentiated the activity of α-LA. Medknow Publications & Media Pvt Ltd 2014 /pmc/articles/PMC4118539/ /pubmed/25097284 http://dx.doi.org/10.4103/0253-7613.135958 Text en Copyright: © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Ivanov, Ivan S.
Sidehmenova, Anastasia V.
Smol’yakova, Vera I.
Chernysheva, Galina A.
Plotnikov, Mark B.
Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro
title Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro
title_full Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro
title_fullStr Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro
title_full_unstemmed Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro
title_short Inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro
title_sort inhibition of adenosine diphosphate-induced platelet aggregation by alpha-lipoic acid and dihydroquercetin in vitro
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118539/
https://www.ncbi.nlm.nih.gov/pubmed/25097284
http://dx.doi.org/10.4103/0253-7613.135958
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