The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter

The methylation of B-cell CLL/lymphoma 6 member B (BCL6B) DNA promoter was detected in several malignancies. Here, we quantitatively detect the methylated status of CpG sites of BCL6B DNA promoter of 459 patients with gastric cancer (GC) by using bisulfite gene sequencing. We show that patients with...

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Autores principales: Deng, Jingyu, Liang, Han, Dong, Qiuping, Hou, Yachao, Xie, Xingming, Yu, Jun, Fan, Daiming, Hao, Xishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118602/
https://www.ncbi.nlm.nih.gov/pubmed/25008234
http://dx.doi.org/10.1098/rsob.140067
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author Deng, Jingyu
Liang, Han
Dong, Qiuping
Hou, Yachao
Xie, Xingming
Yu, Jun
Fan, Daiming
Hao, Xishan
author_facet Deng, Jingyu
Liang, Han
Dong, Qiuping
Hou, Yachao
Xie, Xingming
Yu, Jun
Fan, Daiming
Hao, Xishan
author_sort Deng, Jingyu
collection PubMed
description The methylation of B-cell CLL/lymphoma 6 member B (BCL6B) DNA promoter was detected in several malignancies. Here, we quantitatively detect the methylated status of CpG sites of BCL6B DNA promoter of 459 patients with gastric cancer (GC) by using bisulfite gene sequencing. We show that patients with three or more methylated CpG sites in the BCL6B promoter were significantly associated with poor survival. Furthermore, by using the Akaike information criterion value calculation, we show that the methylated count of BCL6B promoter was identified to be the optimal prognostic predictor of GC patients.
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spelling pubmed-41186022014-08-11 The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter Deng, Jingyu Liang, Han Dong, Qiuping Hou, Yachao Xie, Xingming Yu, Jun Fan, Daiming Hao, Xishan Open Biol Research The methylation of B-cell CLL/lymphoma 6 member B (BCL6B) DNA promoter was detected in several malignancies. Here, we quantitatively detect the methylated status of CpG sites of BCL6B DNA promoter of 459 patients with gastric cancer (GC) by using bisulfite gene sequencing. We show that patients with three or more methylated CpG sites in the BCL6B promoter were significantly associated with poor survival. Furthermore, by using the Akaike information criterion value calculation, we show that the methylated count of BCL6B promoter was identified to be the optimal prognostic predictor of GC patients. The Royal Society 2014-07-09 /pmc/articles/PMC4118602/ /pubmed/25008234 http://dx.doi.org/10.1098/rsob.140067 Text en http://creativecommons.org/licenses/by/3.0/ © 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Research
Deng, Jingyu
Liang, Han
Dong, Qiuping
Hou, Yachao
Xie, Xingming
Yu, Jun
Fan, Daiming
Hao, Xishan
The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter
title The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter
title_full The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter
title_fullStr The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter
title_full_unstemmed The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter
title_short The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter
title_sort survival decrease in gastric cancer is associated with the methylation of b-cell cll/lymphoma 6 member b promoter
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118602/
https://www.ncbi.nlm.nih.gov/pubmed/25008234
http://dx.doi.org/10.1098/rsob.140067
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