Cargando…
Nuclear functions of prefoldin
Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. However, both canonical and prefoldin-like subunits of this heterohex...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118604/ https://www.ncbi.nlm.nih.gov/pubmed/25008233 http://dx.doi.org/10.1098/rsob.140085 |
_version_ | 1782328866098905088 |
---|---|
author | Millán-Zambrano, Gonzalo Chávez, Sebastián |
author_facet | Millán-Zambrano, Gonzalo Chávez, Sebastián |
author_sort | Millán-Zambrano, Gonzalo |
collection | PubMed |
description | Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. However, both canonical and prefoldin-like subunits of this heterohexameric complex have also been found in the nucleus, and are functionally connected with nuclear processes in yeast and metazoa. Plant prefoldin has also been detected in the nucleus and physically associated with a gene regulator. In this review, we summarize the information available on the involvement of prefoldin in nuclear phenomena, place special emphasis on gene transcription, and discuss the possibility of a global coordination between gene regulation and cytoplasmic dynamics mediated by prefoldin. |
format | Online Article Text |
id | pubmed-4118604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-41186042014-08-11 Nuclear functions of prefoldin Millán-Zambrano, Gonzalo Chávez, Sebastián Open Biol Review Prefoldin is a cochaperone, present in all eukaryotes, that cooperates with the chaperonin CCT. It is known mainly for its functional relevance in the cytoplasmic folding of actin and tubulin monomers during cytoskeleton assembly. However, both canonical and prefoldin-like subunits of this heterohexameric complex have also been found in the nucleus, and are functionally connected with nuclear processes in yeast and metazoa. Plant prefoldin has also been detected in the nucleus and physically associated with a gene regulator. In this review, we summarize the information available on the involvement of prefoldin in nuclear phenomena, place special emphasis on gene transcription, and discuss the possibility of a global coordination between gene regulation and cytoplasmic dynamics mediated by prefoldin. The Royal Society 2014-07-09 /pmc/articles/PMC4118604/ /pubmed/25008233 http://dx.doi.org/10.1098/rsob.140085 Text en http://creativecommons.org/licenses/by/3.0/ © 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Review Millán-Zambrano, Gonzalo Chávez, Sebastián Nuclear functions of prefoldin |
title | Nuclear functions of prefoldin |
title_full | Nuclear functions of prefoldin |
title_fullStr | Nuclear functions of prefoldin |
title_full_unstemmed | Nuclear functions of prefoldin |
title_short | Nuclear functions of prefoldin |
title_sort | nuclear functions of prefoldin |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118604/ https://www.ncbi.nlm.nih.gov/pubmed/25008233 http://dx.doi.org/10.1098/rsob.140085 |
work_keys_str_mv | AT millanzambranogonzalo nuclearfunctionsofprefoldin AT chavezsebastian nuclearfunctionsofprefoldin |