Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step

Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype. We developed a computational model of glycolysis and an integr...

Descripción completa

Detalles Bibliográficos
Autores principales: Shestov, Alexander A, Liu, Xiaojing, Ser, Zheng, Cluntun, Ahmad A, Hung, Yin P, Huang, Lei, Kim, Dongsung, Le, Anne, Yellen, Gary, Albeck, John G, Locasale, Jason W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118620/
https://www.ncbi.nlm.nih.gov/pubmed/25009227
http://dx.doi.org/10.7554/eLife.03342

Ejemplares similares

Ejemplares similares