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Creating stable stem regions for loop elongation in Fcabs — Insights from combining yeast surface display, in silico loop reconstruction and molecular dynamics simulations

Fcabs (Fc antigen binding) are crystallizable fragments of IgG where the C-terminal structural loops of the CH3 domain are engineered for antigen binding. For the design of libraries it is beneficial to know positions that will permit loop elongation to increase the potential interaction surface wit...

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Detalles Bibliográficos
Autores principales: Hasenhindl, Christoph, Lai, Balder, Delgado, Javier, Traxlmayr, Michael W., Stadlmayr, Gerhard, Rüker, Florian, Serrano, Luis, Oostenbrink, Chris, Obinger, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Pub. Co 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118681/
https://www.ncbi.nlm.nih.gov/pubmed/24792385
http://dx.doi.org/10.1016/j.bbapap.2014.04.020