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Short- and long-term habituation of auditory event-related potentials in the rat
An auditory oddball paradigm in humans generates a long-duration cortical negative potential, often referred to as mismatch negativity. Similar negativity has been documented in monkeys and cats, but it is controversial whether mismatch negativity also exists in awake rodents. To this end, we record...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118758/ https://www.ncbi.nlm.nih.gov/pubmed/25132958 http://dx.doi.org/10.12688/f1000research.2-182.v2 |
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author | Gurevicius, Kestutis Lipponen, Arto Minkeviciene, Rimante Tanila, Heikki |
author_facet | Gurevicius, Kestutis Lipponen, Arto Minkeviciene, Rimante Tanila, Heikki |
author_sort | Gurevicius, Kestutis |
collection | PubMed |
description | An auditory oddball paradigm in humans generates a long-duration cortical negative potential, often referred to as mismatch negativity. Similar negativity has been documented in monkeys and cats, but it is controversial whether mismatch negativity also exists in awake rodents. To this end, we recorded cortical and hippocampal evoked responses in rats during alert immobility under a typical passive oddball paradigm that yields mismatch negativity in humans. The standard stimulus was a 9 kHz tone and the deviant either 7 or 11 kHz tone in the first condition. We found no evidence of a sustained potential shift when comparing evoked responses to standard and deviant stimuli. Instead, we found repetition-induced attenuation of the P60 component of the combined evoked response in the cortex, but not in the hippocampus. The attenuation extended over three days of recording and disappeared after 20 intervening days of rest. Reversal of the standard and deviant tones resulted is a robust enhancement of the N40 component not only in the cortex but also in the hippocampus. Responses to standard and deviant stimuli were affected similarly. Finally, we tested the effect of scopolamine in this paradigm. Scopolamine attenuated cortical N40 and P60 as well as hippocampal P60 components, but had no specific effect on the deviant response. We conclude that in an oddball paradigm the rat demonstrates repetition-induced attenuation of mid-latency responses, which resembles attenuation of the N1-component of human auditory evoked potential, but no mismatch negativity. |
format | Online Article Text |
id | pubmed-4118758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-41187582014-08-15 Short- and long-term habituation of auditory event-related potentials in the rat Gurevicius, Kestutis Lipponen, Arto Minkeviciene, Rimante Tanila, Heikki F1000Res Research Article An auditory oddball paradigm in humans generates a long-duration cortical negative potential, often referred to as mismatch negativity. Similar negativity has been documented in monkeys and cats, but it is controversial whether mismatch negativity also exists in awake rodents. To this end, we recorded cortical and hippocampal evoked responses in rats during alert immobility under a typical passive oddball paradigm that yields mismatch negativity in humans. The standard stimulus was a 9 kHz tone and the deviant either 7 or 11 kHz tone in the first condition. We found no evidence of a sustained potential shift when comparing evoked responses to standard and deviant stimuli. Instead, we found repetition-induced attenuation of the P60 component of the combined evoked response in the cortex, but not in the hippocampus. The attenuation extended over three days of recording and disappeared after 20 intervening days of rest. Reversal of the standard and deviant tones resulted is a robust enhancement of the N40 component not only in the cortex but also in the hippocampus. Responses to standard and deviant stimuli were affected similarly. Finally, we tested the effect of scopolamine in this paradigm. Scopolamine attenuated cortical N40 and P60 as well as hippocampal P60 components, but had no specific effect on the deviant response. We conclude that in an oddball paradigm the rat demonstrates repetition-induced attenuation of mid-latency responses, which resembles attenuation of the N1-component of human auditory evoked potential, but no mismatch negativity. F1000Research 2014-05-01 /pmc/articles/PMC4118758/ /pubmed/25132958 http://dx.doi.org/10.12688/f1000research.2-182.v2 Text en Copyright: © 2014 Gurevicius K et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/publicdomain/zero/1.0/ Data associated with the article are available under the terms of the Creative Commons Zero "No rights reserved" data waiver (CC0 1.0 Public domain dedication). |
spellingShingle | Research Article Gurevicius, Kestutis Lipponen, Arto Minkeviciene, Rimante Tanila, Heikki Short- and long-term habituation of auditory event-related potentials in the rat |
title | Short- and long-term habituation of auditory event-related potentials in the rat |
title_full | Short- and long-term habituation of auditory event-related potentials in the rat |
title_fullStr | Short- and long-term habituation of auditory event-related potentials in the rat |
title_full_unstemmed | Short- and long-term habituation of auditory event-related potentials in the rat |
title_short | Short- and long-term habituation of auditory event-related potentials in the rat |
title_sort | short- and long-term habituation of auditory event-related potentials in the rat |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118758/ https://www.ncbi.nlm.nih.gov/pubmed/25132958 http://dx.doi.org/10.12688/f1000research.2-182.v2 |
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