The RpfC (Rv1884) atomic structure shows high structural conservation within the resuscitation-promoting factor catalytic domain

The first structure of the catalytic domain of RpfC (Rv1884), one of the resuscitation-promoting factors (RPFs) from Mycobacterium tuberculosis, is reported. The structure was solved using molecular replacement once the space group had been correctly identified as twinned P2(1) rather than the appar...

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Detalles Bibliográficos
Autores principales: Chauviac, Francois-Xavier, Robertson, Giles, Quay, Doris H. X., Bagnéris, Claire, Dumas, Christian, Henderson, Brian, Ward, John, Keep, Nicholas H., Cohen-Gonsaud, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Structural Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118796/
https://www.ncbi.nlm.nih.gov/pubmed/25084374
http://dx.doi.org/10.1107/S2053230X1401317X
Descripción
Sumario:The first structure of the catalytic domain of RpfC (Rv1884), one of the resuscitation-promoting factors (RPFs) from Mycobacterium tuberculosis, is reported. The structure was solved using molecular replacement once the space group had been correctly identified as twinned P2(1) rather than the apparent C222(1) by searching for anomalous scattering sites in P1. The structure displays a very high degree of structural conservation with the previously published structures of the catalytic domains of RpfB (Rv1009) and RpfE (Rv2450). This structural conservation highlights the importance of the versatile domain composition of the RPF family.

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