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Mapping the conformational space accessible to catechol-O-methyltransferase

Methylation catalysed by catechol-O-methyltransferase (COMT) is the main pathway of catechol neurotransmitter deactivation in the prefrontal cortex. Low levels of this class of neurotransmitters are held to be causative of diseases such as schizophrenia, depression and Parkinson’s disease. Inhibitio...

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Detalles Bibliográficos
Autores principales:	Ehler, Andreas, Benz, Jörg, Schlatter, Daniel, Rudolph, Markus G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Union of Crystallography 2014
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118827/ https://www.ncbi.nlm.nih.gov/pubmed/25084335 http://dx.doi.org/10.1107/S1399004714012917

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