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HLA-C -35kb Expression SNP Is Associated with Differential Control of β-HPV Infection in Squamous Cell Carcinoma Cases and Controls

A single nucleotide polymorphism (SNP) 35 kb upstream of the HLA-C gene is associated with HLA-C expression, and the high expressing genotype (CC) has been associated with HIV-I control. HLA-C is unique among the classical MHC class I molecules for its role in the control of viral infections and rec...

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Autores principales: Vineretsky, Karin A., Karagas, Margaret R., Kuriger-Laber, Jacquelyn K., Waterboer, Tim, Pawlita, Michael, Nelson, Heather H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118903/
https://www.ncbi.nlm.nih.gov/pubmed/25083782
http://dx.doi.org/10.1371/journal.pone.0103710
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author Vineretsky, Karin A.
Karagas, Margaret R.
Kuriger-Laber, Jacquelyn K.
Waterboer, Tim
Pawlita, Michael
Nelson, Heather H.
author_facet Vineretsky, Karin A.
Karagas, Margaret R.
Kuriger-Laber, Jacquelyn K.
Waterboer, Tim
Pawlita, Michael
Nelson, Heather H.
author_sort Vineretsky, Karin A.
collection PubMed
description A single nucleotide polymorphism (SNP) 35 kb upstream of the HLA-C gene is associated with HLA-C expression, and the high expressing genotype (CC) has been associated with HIV-I control. HLA-C is unique among the classical MHC class I molecules for its role in the control of viral infections and recognition of abnormal or missing self. This immunosurveillance is central to the pathogenesis of non-melanoma skin cancer (NMSC), and of squamous cell carcinoma (SCC) in particular. While sun exposure is a major risk factor for these cancers, cutaneous infections with genus β-HPV have been implicated in the development of SCC. We hypothesized that the high expression HLA-C genotype is associated with β-HPV infections. Therefore, we investigated the association between β-HPV serology and the −35 kb SNP (rs9264942) in a population-based case-control study of 510 SCC cases and 608 controls. Among controls, the high expression −35 kb SNP genotype (CC) reduced the likelihood of positive serology for multiple (≥2) β-HPV infections (OR = 0.49, 95% CI: 0.25–0.97), and β-HPV species 2 infection (OR = 0.43, 95% CI: 0.23–0.79). However, no association with β-HPV status was observed among SCC cases. Our findings suggest that underlying immunogenotype plays an important role in differential control of β-HPV in SCC cases and controls.
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spelling pubmed-41189032014-08-04 HLA-C -35kb Expression SNP Is Associated with Differential Control of β-HPV Infection in Squamous Cell Carcinoma Cases and Controls Vineretsky, Karin A. Karagas, Margaret R. Kuriger-Laber, Jacquelyn K. Waterboer, Tim Pawlita, Michael Nelson, Heather H. PLoS One Research Article A single nucleotide polymorphism (SNP) 35 kb upstream of the HLA-C gene is associated with HLA-C expression, and the high expressing genotype (CC) has been associated with HIV-I control. HLA-C is unique among the classical MHC class I molecules for its role in the control of viral infections and recognition of abnormal or missing self. This immunosurveillance is central to the pathogenesis of non-melanoma skin cancer (NMSC), and of squamous cell carcinoma (SCC) in particular. While sun exposure is a major risk factor for these cancers, cutaneous infections with genus β-HPV have been implicated in the development of SCC. We hypothesized that the high expression HLA-C genotype is associated with β-HPV infections. Therefore, we investigated the association between β-HPV serology and the −35 kb SNP (rs9264942) in a population-based case-control study of 510 SCC cases and 608 controls. Among controls, the high expression −35 kb SNP genotype (CC) reduced the likelihood of positive serology for multiple (≥2) β-HPV infections (OR = 0.49, 95% CI: 0.25–0.97), and β-HPV species 2 infection (OR = 0.43, 95% CI: 0.23–0.79). However, no association with β-HPV status was observed among SCC cases. Our findings suggest that underlying immunogenotype plays an important role in differential control of β-HPV in SCC cases and controls. Public Library of Science 2014-08-01 /pmc/articles/PMC4118903/ /pubmed/25083782 http://dx.doi.org/10.1371/journal.pone.0103710 Text en © 2014 Vineretsky et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Vineretsky, Karin A.
Karagas, Margaret R.
Kuriger-Laber, Jacquelyn K.
Waterboer, Tim
Pawlita, Michael
Nelson, Heather H.
HLA-C -35kb Expression SNP Is Associated with Differential Control of β-HPV Infection in Squamous Cell Carcinoma Cases and Controls
title HLA-C -35kb Expression SNP Is Associated with Differential Control of β-HPV Infection in Squamous Cell Carcinoma Cases and Controls
title_full HLA-C -35kb Expression SNP Is Associated with Differential Control of β-HPV Infection in Squamous Cell Carcinoma Cases and Controls
title_fullStr HLA-C -35kb Expression SNP Is Associated with Differential Control of β-HPV Infection in Squamous Cell Carcinoma Cases and Controls
title_full_unstemmed HLA-C -35kb Expression SNP Is Associated with Differential Control of β-HPV Infection in Squamous Cell Carcinoma Cases and Controls
title_short HLA-C -35kb Expression SNP Is Associated with Differential Control of β-HPV Infection in Squamous Cell Carcinoma Cases and Controls
title_sort hla-c -35kb expression snp is associated with differential control of β-hpv infection in squamous cell carcinoma cases and controls
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118903/
https://www.ncbi.nlm.nih.gov/pubmed/25083782
http://dx.doi.org/10.1371/journal.pone.0103710
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