Bordetella Adenylate Cyclase Toxin Differentially Modulates Toll-Like Receptor-Stimulated Activation, Migration and T Cell Stimulatory Capacity of Dendritic Cells

Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and delivers into their cytosol an adenylyl cyclase (AC) enzyme that subverts cellular signaling by increasing cAMP levels. In the present study, w...

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Detalles Bibliográficos
Autores principales: Adkins, Irena, Kamanova, Jana, Kocourkova, Aneta, Svedova, Martina, Tomala, Jakub, Janova, Hana, Masin, Jiri, Chladkova, Barbora, Bumba, Ladislav, Kovar, Marek, Ross, Padraig J., Tuckova, Ludmila, Spisek, Radek, Mills, Kingston H. G., Sebo, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118975/
https://www.ncbi.nlm.nih.gov/pubmed/25084094
http://dx.doi.org/10.1371/journal.pone.0104064

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