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A new mechanism for growth hormone receptor activation of JAK2, and implications for related cytokine receptors
The growth hormone receptor was the first cytokine receptor to be cloned and crystallized, and provides a valuable exemplar for activation of its cognate kinase, JAK2. We review progress in understanding its activation mechanism, in particular the molecular movements made by this constitutively dime...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119067/ https://www.ncbi.nlm.nih.gov/pubmed/25101218 http://dx.doi.org/10.4161/jkst.29569 |