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Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes

Telocytes (TCs) are a unique type of interstitial cells with specific, extremely long prolongations named telopodes (Tps). Our previous study showed that TCs are distinct from fibroblasts (Fbs) and mesenchymal stem cells (MSCs) as concerns gene expression and proteomics. The present study explores p...

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Autores principales: Sun, Xiaoru, Zheng, Minghuan, Zhang, Miaomiao, Qian, Mengjia, Zheng, Yonghua, Li, Meiyi, Cretoiu, Dragos, Chen, Chengshui, Chen, Luonan, Popescu, Laurentiu M, Wang, Xiangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119386/
https://www.ncbi.nlm.nih.gov/pubmed/24826900
http://dx.doi.org/10.1111/jcmm.12302
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author Sun, Xiaoru
Zheng, Minghuan
Zhang, Miaomiao
Qian, Mengjia
Zheng, Yonghua
Li, Meiyi
Cretoiu, Dragos
Chen, Chengshui
Chen, Luonan
Popescu, Laurentiu M
Wang, Xiangdong
author_facet Sun, Xiaoru
Zheng, Minghuan
Zhang, Miaomiao
Qian, Mengjia
Zheng, Yonghua
Li, Meiyi
Cretoiu, Dragos
Chen, Chengshui
Chen, Luonan
Popescu, Laurentiu M
Wang, Xiangdong
author_sort Sun, Xiaoru
collection PubMed
description Telocytes (TCs) are a unique type of interstitial cells with specific, extremely long prolongations named telopodes (Tps). Our previous study showed that TCs are distinct from fibroblasts (Fbs) and mesenchymal stem cells (MSCs) as concerns gene expression and proteomics. The present study explores patterns of mouse TC-specific gene profiles on chromosome 1. We investigated the network of main genes and the potential functional correlations. We compared gene expression profiles of mouse pulmonary TCs, MSCs, Fbs, alveolar type II cells (ATII), airway basal cells (ABCs), proximal airway cells (PACs), CD8(+) T cells from bronchial lymph nodes (T-BL) and CD8(+) T cells from lungs (T-LL). The functional and feature networks were identified and compared by bioinformatics tools. Our data showed that on TC chromosome 1, there are about 25% up-regulated and 70% down-regulated genes (more than onefold) as compared with the other cells respectively. Capn2, Fhl2 and Qsox1 were over-expressed in TCs compared to the other cells, indicating that biological functions of TCs are mainly associated with morphogenesis and local tissue homoeostasis. TCs seem to have important roles in the prevention of tissue inflammation and fibrogenesis development in lung inflammatory diseases and as modulators of immune cell response. In conclusion, TCs are distinct from the other cell types.
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spelling pubmed-41193862014-12-03 Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes Sun, Xiaoru Zheng, Minghuan Zhang, Miaomiao Qian, Mengjia Zheng, Yonghua Li, Meiyi Cretoiu, Dragos Chen, Chengshui Chen, Luonan Popescu, Laurentiu M Wang, Xiangdong J Cell Mol Med Original Articles Telocytes (TCs) are a unique type of interstitial cells with specific, extremely long prolongations named telopodes (Tps). Our previous study showed that TCs are distinct from fibroblasts (Fbs) and mesenchymal stem cells (MSCs) as concerns gene expression and proteomics. The present study explores patterns of mouse TC-specific gene profiles on chromosome 1. We investigated the network of main genes and the potential functional correlations. We compared gene expression profiles of mouse pulmonary TCs, MSCs, Fbs, alveolar type II cells (ATII), airway basal cells (ABCs), proximal airway cells (PACs), CD8(+) T cells from bronchial lymph nodes (T-BL) and CD8(+) T cells from lungs (T-LL). The functional and feature networks were identified and compared by bioinformatics tools. Our data showed that on TC chromosome 1, there are about 25% up-regulated and 70% down-regulated genes (more than onefold) as compared with the other cells respectively. Capn2, Fhl2 and Qsox1 were over-expressed in TCs compared to the other cells, indicating that biological functions of TCs are mainly associated with morphogenesis and local tissue homoeostasis. TCs seem to have important roles in the prevention of tissue inflammation and fibrogenesis development in lung inflammatory diseases and as modulators of immune cell response. In conclusion, TCs are distinct from the other cell types. BlackWell Publishing Ltd 2014-05 2014-05-15 /pmc/articles/PMC4119386/ /pubmed/24826900 http://dx.doi.org/10.1111/jcmm.12302 Text en © 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Sun, Xiaoru
Zheng, Minghuan
Zhang, Miaomiao
Qian, Mengjia
Zheng, Yonghua
Li, Meiyi
Cretoiu, Dragos
Chen, Chengshui
Chen, Luonan
Popescu, Laurentiu M
Wang, Xiangdong
Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes
title Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes
title_full Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes
title_fullStr Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes
title_full_unstemmed Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes
title_short Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes
title_sort differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type ii cells, airway epithelial cells and lymphocytes
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119386/
https://www.ncbi.nlm.nih.gov/pubmed/24826900
http://dx.doi.org/10.1111/jcmm.12302
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