Dissecting the mechanisms underlying the accumulation of mitochondrial DNA deletions in human skeletal muscle

Large-scale mitochondrial DNA (mtDNA) deletions are an important cause of mitochondrial disease, while somatic mtDNA deletions cause focal respiratory chain deficiency associated with ageing and neurodegenerative disorders. As mtDNA deletions only cause cellular pathology at high levels of mtDNA het...

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Detalles Bibliográficos
Autores principales: Campbell, Georgia, Krishnan, Kim J., Deschauer, Marcus, Taylor, Robert W., Turnbull, Doug M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119413/
https://www.ncbi.nlm.nih.gov/pubmed/24740879
http://dx.doi.org/10.1093/hmg/ddu176

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