Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells

Trophoblast invasion into uterine tissues represents a hallmark of first trimester placental development. As expression of serum amyloid A4 (SAA4) occurs in tumorigenic and invasive tissues we here investigated whether SAA4 is present in trophoblast-like human AC1-M59/Jeg-3 cells and trophoblast pre...

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Detalles Bibliográficos
Autores principales: Rossmann, C., Hammer, A., Koyani, C.N., Kovacevic, A., Siwetz, M., Desoye, G., Poehlmann, T.G., Markert, U.R., Huppertz, B., Sattler, W., Malle, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119475/
https://www.ncbi.nlm.nih.gov/pubmed/24951172
http://dx.doi.org/10.1016/j.placenta.2014.05.012
Descripción
Sumario:Trophoblast invasion into uterine tissues represents a hallmark of first trimester placental development. As expression of serum amyloid A4 (SAA4) occurs in tumorigenic and invasive tissues we here investigated whether SAA4 is present in trophoblast-like human AC1-M59/Jeg-3 cells and trophoblast preparations of human first trimester and term placenta. SAA4 mRNA was expressed in non-stimulated and cytokine-treated AC1-M59/Jeg-3 cells. In purified trophoblast cells SAA4 mRNA expression was upregulated at weeks 10 and 12 of pregnancy. Western-blot and immunohistochemical staining of first trimester placental tissue revealed pronounced SAA4 expression in invasive trophoblast cells indicating a potential role of SAA4 during invasion.

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