Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells

Trophoblast invasion into uterine tissues represents a hallmark of first trimester placental development. As expression of serum amyloid A4 (SAA4) occurs in tumorigenic and invasive tissues we here investigated whether SAA4 is present in trophoblast-like human AC1-M59/Jeg-3 cells and trophoblast pre...

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Autores principales: Rossmann, C., Hammer, A., Koyani, C.N., Kovacevic, A., Siwetz, M., Desoye, G., Poehlmann, T.G., Markert, U.R., Huppertz, B., Sattler, W., Malle, E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: W.B. Saunders 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119475/
https://www.ncbi.nlm.nih.gov/pubmed/24951172
http://dx.doi.org/10.1016/j.placenta.2014.05.012
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author Rossmann, C.
Hammer, A.
Koyani, C.N.
Kovacevic, A.
Siwetz, M.
Desoye, G.
Poehlmann, T.G.
Markert, U.R.
Huppertz, B.
Sattler, W.
Malle, E.
author_facet Rossmann, C.
Hammer, A.
Koyani, C.N.
Kovacevic, A.
Siwetz, M.
Desoye, G.
Poehlmann, T.G.
Markert, U.R.
Huppertz, B.
Sattler, W.
Malle, E.
author_sort Rossmann, C.
collection PubMed
description Trophoblast invasion into uterine tissues represents a hallmark of first trimester placental development. As expression of serum amyloid A4 (SAA4) occurs in tumorigenic and invasive tissues we here investigated whether SAA4 is present in trophoblast-like human AC1-M59/Jeg-3 cells and trophoblast preparations of human first trimester and term placenta. SAA4 mRNA was expressed in non-stimulated and cytokine-treated AC1-M59/Jeg-3 cells. In purified trophoblast cells SAA4 mRNA expression was upregulated at weeks 10 and 12 of pregnancy. Western-blot and immunohistochemical staining of first trimester placental tissue revealed pronounced SAA4 expression in invasive trophoblast cells indicating a potential role of SAA4 during invasion.
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spelling pubmed-41194752014-08-02 Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells Rossmann, C. Hammer, A. Koyani, C.N. Kovacevic, A. Siwetz, M. Desoye, G. Poehlmann, T.G. Markert, U.R. Huppertz, B. Sattler, W. Malle, E. Placenta Short Communication Trophoblast invasion into uterine tissues represents a hallmark of first trimester placental development. As expression of serum amyloid A4 (SAA4) occurs in tumorigenic and invasive tissues we here investigated whether SAA4 is present in trophoblast-like human AC1-M59/Jeg-3 cells and trophoblast preparations of human first trimester and term placenta. SAA4 mRNA was expressed in non-stimulated and cytokine-treated AC1-M59/Jeg-3 cells. In purified trophoblast cells SAA4 mRNA expression was upregulated at weeks 10 and 12 of pregnancy. Western-blot and immunohistochemical staining of first trimester placental tissue revealed pronounced SAA4 expression in invasive trophoblast cells indicating a potential role of SAA4 during invasion. W.B. Saunders 2014-08 /pmc/articles/PMC4119475/ /pubmed/24951172 http://dx.doi.org/10.1016/j.placenta.2014.05.012 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Short Communication
Rossmann, C.
Hammer, A.
Koyani, C.N.
Kovacevic, A.
Siwetz, M.
Desoye, G.
Poehlmann, T.G.
Markert, U.R.
Huppertz, B.
Sattler, W.
Malle, E.
Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells
title Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells
title_full Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells
title_fullStr Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells
title_full_unstemmed Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells
title_short Expression of serum amyloid A4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells
title_sort expression of serum amyloid a4 in human trophoblast-like choriocarcinoma cell lines and human first trimester/term trophoblast cells
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119475/
https://www.ncbi.nlm.nih.gov/pubmed/24951172
http://dx.doi.org/10.1016/j.placenta.2014.05.012
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