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Melatonin analgesia is associated with improvement of the descending endogenous pain-modulating system in fibromyalgia: a phase II, randomized, double-dummy, controlled trial

BACKGROUND: Central disinhibition is a mechanism involved in the physiopathology of fibromyalgia. Melatonin can improve sleep quality, pain and pain threshold. We hypothesized that treatment with melatonin alone or in combination with amitriptyline would be superior to amitriptyline alone in modifyi...

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Detalles Bibliográficos
Autores principales:	de Zanette, Simone Azevedo, Vercelino, Rafael, Laste, Gabriela, Rozisky, Joanna Ripoll, Schwertner, André, Machado, Caroline Buzzatti, Xavier, Fernando, de Souza, Izabel Cristina Custódio, Deitos, Alicia, Torres, Iraci L S, Caumo, Wolnei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119581/ https://www.ncbi.nlm.nih.gov/pubmed/25052847 http://dx.doi.org/10.1186/2050-6511-15-40

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