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Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly

Aging increases the risk for cardiovascular morbidity and mortality. Chronic low-grade inflammation deteriorates vascular function, increases age-related vascular stiffness, and affects hemodynamics. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a major mediator of ath...

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Autores principales: Rammos, Christos, Hendgen-Cotta, Ulrike B., Pohl, Julia, Totzeck, Matthias, Luedike, Peter, Schulze, Volker T., Kelm, Malte, Rassaf, Tienush
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119621/
https://www.ncbi.nlm.nih.gov/pubmed/25114912
http://dx.doi.org/10.1155/2014/582586
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author Rammos, Christos
Hendgen-Cotta, Ulrike B.
Pohl, Julia
Totzeck, Matthias
Luedike, Peter
Schulze, Volker T.
Kelm, Malte
Rassaf, Tienush
author_facet Rammos, Christos
Hendgen-Cotta, Ulrike B.
Pohl, Julia
Totzeck, Matthias
Luedike, Peter
Schulze, Volker T.
Kelm, Malte
Rassaf, Tienush
author_sort Rammos, Christos
collection PubMed
description Aging increases the risk for cardiovascular morbidity and mortality. Chronic low-grade inflammation deteriorates vascular function, increases age-related vascular stiffness, and affects hemodynamics. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a major mediator of atherosclerosis. Plasma MIF levels are associated with arterial stiffness, a hallmark of vascular aging. Preclinical studies show that blockade of MIF leads to atherosclerotic plaque regression. Nutritional approaches provide opportunities to counteract age-related inflammation. Following a chronic dietary supplementation with the micronutrient nitrate has been demonstrated to improve vascular stiffness. Whether dietary nitrate affects circulating MIF levels is not known. In a randomized placebo-controlled, double-blinded study, elderly subjects received a dietary nitrate supplementation for 4 weeks. Dietary nitrate led to a decrease in plasma MIF levels in the elderly and to an improvement in vascular functions. This was associated with a reduction in central systolic blood pressure. Our data show that supplementation with dietary nitrate is associated with a reduction of circulating MIF levels along with an improvement in vascular function. This supports the concept of dietary approaches to modulate age-related changes of vascular functions.
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spelling pubmed-41196212014-08-11 Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly Rammos, Christos Hendgen-Cotta, Ulrike B. Pohl, Julia Totzeck, Matthias Luedike, Peter Schulze, Volker T. Kelm, Malte Rassaf, Tienush Biomed Res Int Research Article Aging increases the risk for cardiovascular morbidity and mortality. Chronic low-grade inflammation deteriorates vascular function, increases age-related vascular stiffness, and affects hemodynamics. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a major mediator of atherosclerosis. Plasma MIF levels are associated with arterial stiffness, a hallmark of vascular aging. Preclinical studies show that blockade of MIF leads to atherosclerotic plaque regression. Nutritional approaches provide opportunities to counteract age-related inflammation. Following a chronic dietary supplementation with the micronutrient nitrate has been demonstrated to improve vascular stiffness. Whether dietary nitrate affects circulating MIF levels is not known. In a randomized placebo-controlled, double-blinded study, elderly subjects received a dietary nitrate supplementation for 4 weeks. Dietary nitrate led to a decrease in plasma MIF levels in the elderly and to an improvement in vascular functions. This was associated with a reduction in central systolic blood pressure. Our data show that supplementation with dietary nitrate is associated with a reduction of circulating MIF levels along with an improvement in vascular function. This supports the concept of dietary approaches to modulate age-related changes of vascular functions. Hindawi Publishing Corporation 2014 2014-07-08 /pmc/articles/PMC4119621/ /pubmed/25114912 http://dx.doi.org/10.1155/2014/582586 Text en Copyright © 2014 Christos Rammos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rammos, Christos
Hendgen-Cotta, Ulrike B.
Pohl, Julia
Totzeck, Matthias
Luedike, Peter
Schulze, Volker T.
Kelm, Malte
Rassaf, Tienush
Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly
title Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly
title_full Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly
title_fullStr Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly
title_full_unstemmed Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly
title_short Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly
title_sort modulation of circulating macrophage migration inhibitory factor in the elderly
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119621/
https://www.ncbi.nlm.nih.gov/pubmed/25114912
http://dx.doi.org/10.1155/2014/582586
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