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Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly
Aging increases the risk for cardiovascular morbidity and mortality. Chronic low-grade inflammation deteriorates vascular function, increases age-related vascular stiffness, and affects hemodynamics. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a major mediator of ath...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119621/ https://www.ncbi.nlm.nih.gov/pubmed/25114912 http://dx.doi.org/10.1155/2014/582586 |
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author | Rammos, Christos Hendgen-Cotta, Ulrike B. Pohl, Julia Totzeck, Matthias Luedike, Peter Schulze, Volker T. Kelm, Malte Rassaf, Tienush |
author_facet | Rammos, Christos Hendgen-Cotta, Ulrike B. Pohl, Julia Totzeck, Matthias Luedike, Peter Schulze, Volker T. Kelm, Malte Rassaf, Tienush |
author_sort | Rammos, Christos |
collection | PubMed |
description | Aging increases the risk for cardiovascular morbidity and mortality. Chronic low-grade inflammation deteriorates vascular function, increases age-related vascular stiffness, and affects hemodynamics. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a major mediator of atherosclerosis. Plasma MIF levels are associated with arterial stiffness, a hallmark of vascular aging. Preclinical studies show that blockade of MIF leads to atherosclerotic plaque regression. Nutritional approaches provide opportunities to counteract age-related inflammation. Following a chronic dietary supplementation with the micronutrient nitrate has been demonstrated to improve vascular stiffness. Whether dietary nitrate affects circulating MIF levels is not known. In a randomized placebo-controlled, double-blinded study, elderly subjects received a dietary nitrate supplementation for 4 weeks. Dietary nitrate led to a decrease in plasma MIF levels in the elderly and to an improvement in vascular functions. This was associated with a reduction in central systolic blood pressure. Our data show that supplementation with dietary nitrate is associated with a reduction of circulating MIF levels along with an improvement in vascular function. This supports the concept of dietary approaches to modulate age-related changes of vascular functions. |
format | Online Article Text |
id | pubmed-4119621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41196212014-08-11 Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly Rammos, Christos Hendgen-Cotta, Ulrike B. Pohl, Julia Totzeck, Matthias Luedike, Peter Schulze, Volker T. Kelm, Malte Rassaf, Tienush Biomed Res Int Research Article Aging increases the risk for cardiovascular morbidity and mortality. Chronic low-grade inflammation deteriorates vascular function, increases age-related vascular stiffness, and affects hemodynamics. The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a major mediator of atherosclerosis. Plasma MIF levels are associated with arterial stiffness, a hallmark of vascular aging. Preclinical studies show that blockade of MIF leads to atherosclerotic plaque regression. Nutritional approaches provide opportunities to counteract age-related inflammation. Following a chronic dietary supplementation with the micronutrient nitrate has been demonstrated to improve vascular stiffness. Whether dietary nitrate affects circulating MIF levels is not known. In a randomized placebo-controlled, double-blinded study, elderly subjects received a dietary nitrate supplementation for 4 weeks. Dietary nitrate led to a decrease in plasma MIF levels in the elderly and to an improvement in vascular functions. This was associated with a reduction in central systolic blood pressure. Our data show that supplementation with dietary nitrate is associated with a reduction of circulating MIF levels along with an improvement in vascular function. This supports the concept of dietary approaches to modulate age-related changes of vascular functions. Hindawi Publishing Corporation 2014 2014-07-08 /pmc/articles/PMC4119621/ /pubmed/25114912 http://dx.doi.org/10.1155/2014/582586 Text en Copyright © 2014 Christos Rammos et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Rammos, Christos Hendgen-Cotta, Ulrike B. Pohl, Julia Totzeck, Matthias Luedike, Peter Schulze, Volker T. Kelm, Malte Rassaf, Tienush Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly |
title | Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly |
title_full | Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly |
title_fullStr | Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly |
title_full_unstemmed | Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly |
title_short | Modulation of Circulating Macrophage Migration Inhibitory Factor in the Elderly |
title_sort | modulation of circulating macrophage migration inhibitory factor in the elderly |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119621/ https://www.ncbi.nlm.nih.gov/pubmed/25114912 http://dx.doi.org/10.1155/2014/582586 |
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