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Advances in Miniaturized Instruments for Genomics
In recent years, a lot of demonstrations of the miniaturized instruments were reported for genomic applications. They provided the advantages of miniaturization, automation, sensitivity, and specificity for the development of point-of-care diagnostics. The aim of this paper is to report on recent de...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119693/ https://www.ncbi.nlm.nih.gov/pubmed/25114919 http://dx.doi.org/10.1155/2014/734675 |
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author | Gong, Cihun-Siyong Alex Lei, Kin Fong |
author_facet | Gong, Cihun-Siyong Alex Lei, Kin Fong |
author_sort | Gong, Cihun-Siyong Alex |
collection | PubMed |
description | In recent years, a lot of demonstrations of the miniaturized instruments were reported for genomic applications. They provided the advantages of miniaturization, automation, sensitivity, and specificity for the development of point-of-care diagnostics. The aim of this paper is to report on recent developments on miniaturized instruments for genomic applications. Based on the mature development of microfabrication, microfluidic systems have been demonstrated for various genomic detections. Since one of the objectives of miniaturized instruments is for the development of point-of-care device, impedimetric detection is found to be a promising technique for this purpose. An in-depth discussion of the impedimetric circuits and systems will be included to provide total consideration of the miniaturized instruments and their potential application towards real-time portable imaging in the “-omics” era. The current excellent demonstrations suggest a solid foundation for the development of practical and widespread point-of-care genomic diagnostic devices. |
format | Online Article Text |
id | pubmed-4119693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-41196932014-08-11 Advances in Miniaturized Instruments for Genomics Gong, Cihun-Siyong Alex Lei, Kin Fong Biomed Res Int Review Article In recent years, a lot of demonstrations of the miniaturized instruments were reported for genomic applications. They provided the advantages of miniaturization, automation, sensitivity, and specificity for the development of point-of-care diagnostics. The aim of this paper is to report on recent developments on miniaturized instruments for genomic applications. Based on the mature development of microfabrication, microfluidic systems have been demonstrated for various genomic detections. Since one of the objectives of miniaturized instruments is for the development of point-of-care device, impedimetric detection is found to be a promising technique for this purpose. An in-depth discussion of the impedimetric circuits and systems will be included to provide total consideration of the miniaturized instruments and their potential application towards real-time portable imaging in the “-omics” era. The current excellent demonstrations suggest a solid foundation for the development of practical and widespread point-of-care genomic diagnostic devices. Hindawi Publishing Corporation 2014 2014-05-29 /pmc/articles/PMC4119693/ /pubmed/25114919 http://dx.doi.org/10.1155/2014/734675 Text en Copyright © 2014 C.- S. A. Gong and K. F. Lei. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Gong, Cihun-Siyong Alex Lei, Kin Fong Advances in Miniaturized Instruments for Genomics |
title | Advances in Miniaturized Instruments for Genomics |
title_full | Advances in Miniaturized Instruments for Genomics |
title_fullStr | Advances in Miniaturized Instruments for Genomics |
title_full_unstemmed | Advances in Miniaturized Instruments for Genomics |
title_short | Advances in Miniaturized Instruments for Genomics |
title_sort | advances in miniaturized instruments for genomics |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119693/ https://www.ncbi.nlm.nih.gov/pubmed/25114919 http://dx.doi.org/10.1155/2014/734675 |
work_keys_str_mv | AT gongcihunsiyongalex advancesinminiaturizedinstrumentsforgenomics AT leikinfong advancesinminiaturizedinstrumentsforgenomics |