EphA2 Promotes Infiltrative Invasion of Glioma Stem Cells in vivo through Crosstalk with Akt and Regulates Stem Properties

Diffuse infiltrative invasion is a major cause for the dismal prognosis of glioblastoma (GBM), but the underlying mechanisms remain incompletely understood. Using human glioblastoma stem cells (GSCs) that recapitulate the invasive propensity of primary GBM, we find that EphA2 critically regulates GB...

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Detalles Bibliográficos
Autores principales: Miao, Hui, Gale, Nickolas W., Guo, Hong, Qian, Juan, Petty, Aaron, Kaspar, James, Murphy, Andrew J., Valenzuela, David M., Yancopoulos, George, Hambardzumyan, Dolores, Lathia, Justin D., Rich, Jeremy N., Lee, Jeongwu, Wang, Bingcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119862/
https://www.ncbi.nlm.nih.gov/pubmed/24488013
http://dx.doi.org/10.1038/onc.2013.590

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